唐氏综合征中的甲状腺功能。

Thyroid function in Down syndrome.

作者信息

Iughetti Lorenzo, Lucaccioni Laura, Fugetto Francesco, Mason Avril, Predieri Barbara

机构信息

a 1 Department of Medical and Surgical sciences of Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo no 71, 41124, Modena, Italy.

b 2 Developmental Endocrinology Research Group, University of Glasgow, Royal Hospital for Sick Children, G3 8SJ, UK.

出版信息

Expert Rev Endocrinol Metab. 2015 Sep;10(5):525-532. doi: 10.1586/17446651.2015.1063995. Epub 2015 Jul 1.

DOI:10.1586/17446651.2015.1063995

PMID:30298764

Abstract

Down syndrome is the most commonly encountered human chromosomal disorder. Down syndrome is associated with thyroid dysfunction including: hypothyroidism, both congenital and acquired, and hyperthyroidism. A genetic predisposition and a propensity to acquire autoimmune disorders seem to be possible factors, though their causal relation remains unclear. The aim of the review is to describe what is currently known about the association between Down syndrome and thyroid dysfunction.

摘要

唐氏综合征是最常见的人类染色体疾病。唐氏综合征与甲状腺功能障碍有关，包括先天性和后天性甲状腺功能减退以及甲状腺功能亢进。遗传易感性和患自身免疫性疾病的倾向似乎是可能的因素，尽管它们之间的因果关系尚不清楚。本综述的目的是描述目前已知的唐氏综合征与甲状腺功能障碍之间的关联。