Paulin T, Ringdén O, Nilsson B, Lönnqvist B, Gahrton G
Transplantation. 1987 Mar;43(3):393-8. doi: 10.1097/00007890-198703000-00015.
Sixty-seven consecutive patients with aplastic anemia or leukemia who had been treated by allogeneic marrow transplantation and had survived for more than 1 month were surveyed in order to determine the incidence of nonviral infections occurring from 1 month to 3 years after transplantation. Twenty-eight of the 67 patients had one or more infections during this period. Around 20% suffered from pulmonary infections and 20% were classified as having a systemic infection. Ten patients died of bacterial or fungal infection, of whom 6 had graft-versus-host disease. In multivariate analyses acute graft-versus-host disease (P less than 0.0009), splenectomy (P less than 0.02), cytomegalovirus infection (P less than 0.05), and a low marrow cell dose (P less than 0.07) were correlated with nonviral infections.
为了确定异基因骨髓移植后1个月至3年期间非病毒感染的发生率，我们对67例接受异基因骨髓移植且存活超过1个月的再生障碍性贫血或白血病患者进行了连续调查。67例患者中有28例在此期间发生了1次或多次感染。约20%的患者发生肺部感染，20%的患者被归类为全身性感染。10例患者死于细菌或真菌感染，其中6例患有移植物抗宿主病。在多变量分析中，急性移植物抗宿主病（P<0.0009）、脾切除术（P<0.02）、巨细胞病毒感染（P<0.05）和低骨髓细胞剂量（P<0.07）与非病毒感染相关。
