约旦西尼罗河病毒的血清流行率、风险因素和空间分布。

Seroprevalence, risk factors and spatial distribution of West Nile virus in Jordan.

机构信息

Department of Veterinary Pathology and Public Health, Faculty of Veterinary Medicine, Jordan University of Science and Technology, Ar-Ramtha, Irbid, Jordan.

Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA.

出版信息

Trans R Soc Trop Med Hyg. 2019 Jan 1;113(1):24-30. doi: 10.1093/trstmh/try111.

DOI:10.1093/trstmh/try111

PMID:30299511

Abstract

BACKGROUND

This is the first countrywide study of the seroprevalence, risk factors and spatial distribution of West Nile virus (WNV) in Jordan.

METHODS

A cross-sectional sample of 801 participants was administered a comprehensive questionnaire survey and tested for WNV immunoglobulin G antibodies.

RESULTS

The point seroprevalence rate for WNV infection was 8.61% (95% confidence interval 6.8 to 10.8). Multivariate regression analysis demonstrated that sex, age, climate, income and drinking water source were significantly associated with seropositivity (p≤0.05). Males had 1.73 greater odds of infection compared with females. Compared with 15 to 29-year-olds, adults 30-49 y old and adults ≥50 y old had 2.0 and 3.1 greater odds of infection, respectively. Individuals living in the Jordan Valley and Badia had 22.2 and 7.2 times greater odds of infection, respectively, compared with individuals living in the highlands. Households with an income of <US$750/month had 1.8 greater odds of infection compared with those with higher household incomes. Individuals using spring lakes as a drinking water source had 5.1 greater odds of infection than people who used water from any other source.

CONCLUSIONS

This study demonstrates that WNV is circulating in Jordan and should be considered as a differential diagnosis in medical cases presenting with nervous system symptoms, especially for older populations living in the Jordan Valley and Badia areas.

摘要

背景

这是约旦首次对西尼罗河病毒（WNV）的血清流行率、风险因素和空间分布进行的全国性研究。

方法

对 801 名参与者进行了横断面样本调查，他们接受了全面的问卷调查并接受了 WNV 免疫球蛋白 G 抗体检测。

结果

WNV 感染的点血清流行率为 8.61%（95%置信区间为 6.8 至 10.8）。多变量回归分析表明，性别、年龄、气候、收入和饮用水源与血清阳性率显著相关（p≤0.05）。与女性相比，男性感染的可能性高 1.73 倍。与 15 至 29 岁的人相比，30-49 岁和≥50 岁的成年人感染的可能性分别高 2.0 倍和 3.1 倍。与居住在高地的人相比，居住在约旦河谷和贝都因人地区的人感染的可能性分别高 22.2 倍和 7.2 倍。收入低于 750 美元/月的家庭感染的可能性比收入较高的家庭高 1.8 倍。使用泉水湖作为饮用水源的人感染的可能性比使用任何其他水源的人高 5.1 倍。