肥胖儿童和成纤维细胞生长因子1的特征分析
Characterization of fibroblast growth factor 1 in obese children and adolescents.
作者信息
Wang Anru, Yan Xueqin, Zhang Cai, Du Caiqi, Long Wenjun, Zhan Di, Luo Xiaoping
机构信息
Department of Pediatrics, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Department of Pediatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China
出版信息
Endocr Connect. 2018 Aug 1;7(8):932-940. doi: 10.1530/EC-18-0141.
BACKGROUND
Fibroblast growth factor 1 (FGF1) can regulate glucose and lipid metabolism in obese mice. Serum FGF1 has increased in type 2 diabetes mellitus adults and correlated with BMI. This study aimed to indicate conventional weight loss effects on FGF1 in obese children and adolescents.
MATERIALS AND METHODS
Clinical and metabolic parameters of 88 lean and obese individuals (ages 5–15 years) and 39 obese individuals followed with 6 months of lifestyle intervention were collected. Serum FGF1 levels were detected through enzyme-linked immunosorbent assays.
RESULTS
FGF1 levels were increased in obese individuals. Serum FGF1 levels were significantly correlated with BMI and waist circumferences (r = 0.377, P = 0.012; r = 0.301, P = 0.047, respectively). Multivariate stepwise linear regression analyses showed that FGF1 levels were significantly correlated with HbA1c and HOMA-IR (β = 0.371, P = 0.008; β = 0.323, P = 0.021, respectively). Weight loss (2.3 ± 0.1 kg) was accompanied by a significant reduction of circulating FGF1 levels (7.2 ± 0.4 pg/mL). Changes in FGF1 were significantly correlated with changes in fasting glucose, HOMA-IR and low-density lipoprotein cholesterol (β = 0.277, P = 0.020; β = 0.474, P < 0.001; β = 0.320, P = 0.008, respectively).
CONCLUSION
FGF1 levels were increased in obese individuals. Serum FGF1 levels were significantly correlated with BMI and waist circumferences (r = 0.377, P = 0.012; r = 0.301, P = 0.047, respectively). Multivariate stepwise linear regression analyses showed that FGF1 levels were significantly correlated with HbA1c and HOMA-IR (β = 0.371, P = 0.008; β = 0.323, P = 0.021, respectively). Weight loss (2.3 ± 0.1 kg) was accompanied by a significant reduction of circulating FGF1 levels (7.2 ± 0.4 pg/mL). Changes in FGF1 were significantly correlated with changes in fasting glucose, HOMA-IR and low-density lipoprotein cholesterol (β = 0.277, P = 0.020; β = 0.474, P < 0.001; β = 0.320, P = 0.008, respectively).
背景
成纤维细胞生长因子1（FGF1）可调节肥胖小鼠的糖脂代谢。2型糖尿病成年患者血清FGF1水平升高，且与体重指数（BMI）相关。本研究旨在探讨传统减肥方法对肥胖儿童及青少年FGF1的影响。
材料与方法
收集88名体重正常及肥胖个体（年龄5 - 15岁）以及39名接受6个月生活方式干预的肥胖个体的临床和代谢参数。通过酶联免疫吸附测定法检测血清FGF1水平。
结果
肥胖个体的FGF1水平升高。血清FGF1水平与BMI及腰围显著相关（r分别为0.377，P = 0.012；r为0.301，P = 0.047）。多因素逐步线性回归分析显示，FGF1水平与糖化血红蛋白（HbA1c）及胰岛素抵抗指数（HOMA - IR）显著相关（β分别为0.371，P = 0.008；β为0.323，P = 0.021）。体重减轻（2.3±0.1 kg）伴随着循环FGF1水平显著降低（7.2±0.4 pg/mL）。FGF1的变化与空腹血糖、HOMA - IR及低密度脂蛋白胆固醇的变化显著相关（β分别为0.277，P = 0.020；β为0.474，P < 0.001；β为0.320，P = 0.008）。
结论
肥胖个体的FGF1水平升高。血清FGF1水平与BMI及腰围显著相关（r分别为0.377，P = 0.012；r为0.301，P = 0.047）。多因素逐步线性回归分析显示，FGF1水平与HbA1c及HOMA - IR显著相关（β分别为0.371，P = 0.008；β为0.323，P = 0.021）。体重减轻（2.3±0.1 kg）伴随着循环FGF1水平显著降低（7.2±0.4 pg/mL）。FGF1的变化与空腹血糖、HOMA - IR及低密度脂蛋白胆固醇的变化显著相关（β分别为0.277，P = 0.020；β为0.474，P < 0.001；β为0.320，P = 0.008）。
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