Kozlovskiĭ V L
Zh Evol Biokhim Fiziol. 1986 Nov-Dec;22(6):543-7.
Studies have been made on the effect of GABA mimetics on epileptogenic focus in the hippocamp of growing rats. By the pattern of inhibition of this focus by these drugs, it is possible to evaluate the degree of functional maturation of the activity of GABA receptors, glial and neuronal uptake of GABA, and the activity of GABA-T. Higher sensitivity of GABA receptors in younger animals was found together with a higher functional role of glial uptake in GABA utilization. Functional activity of GABA-T and neuronal uptake of the mediator are of lower physiological significance in younger animals as compared to those in adults.
已经对γ-氨基丁酸（GABA）模拟物对生长中大鼠海马癫痫病灶的影响进行了研究。通过这些药物对该病灶的抑制模式，可以评估GABA受体活性、GABA的胶质细胞和神经元摄取以及GABA转氨酶（GABA-T）活性的功能成熟程度。发现幼龄动物的GABA受体敏感性更高，同时胶质细胞摄取在GABA利用中的功能作用也更大。与成年动物相比，幼龄动物中GABA-T的功能活性和介质的神经元摄取的生理意义较低。
