Aydin Elçin, Altin Cihan, Özcan Söylev Gözde, Tekindal Mustafa Agah, Ağildere Muhteşem
Departments of Radiology.
Cardiology, and.
Ultrasound Q. 2019 Jun;35(2):142-146. doi: 10.1097/RUQ.0000000000000386.
Patients with vitamin D deficiency (VDD) have potential to have increased cardiovascular morbidity and mortality. In this study, we aimed to discover the findings of early atherosclerosis in patients with VDD by measuring carotid intima-media thickness (CIMT) and epicardial fat thickness (EFT).
The study population includes 52 patients with VDD (n = 30 [57% female], mean ± SD age 54.28 ± 8.77 years, mean ± SD serum 25-hydroxyvitamin D (25 [OH] D) 11 ± 2.4 ng/mL) and 82 participants for control group (n = 52 [63.4% female], mean ± SD age 56.40 ± 7.90 years, mean ± SD serum (25 [OH] D) 53 ± 4.2 ng/mL) who have no cardiovascular disease. Carotid intima-media thickness was assessed by using ultrasonography, and EFT was measured on the free wall of the right ventricle at end diastole from the parasternal long-axis views by standard transthoracic 2-dimensional echocardiography.
Both CIMT and EFT were significantly higher in patients with VDD compared with controls (0.75 ± 0.16 mm vs 0.68 ± 0.21 mm, P < 0.05, and 0.66 ± 0.15 cm vs 0.56 ± 0.15 cm, P < 0.001).
Patients with VDD seem to have increased CIMT and EFT, which are predictors of atherosclerotic process. Further studies are needed to confirm these results.
维生素D缺乏（VDD）患者有心血管疾病发病率和死亡率增加的潜在风险。在本研究中，我们旨在通过测量颈动脉内膜中层厚度（CIMT）和心外膜脂肪厚度（EFT）来发现VDD患者早期动脉粥样硬化的表现。
研究人群包括52例VDD患者（n = 30 [57%为女性]，平均±标准差年龄54.28±8.77岁，平均±标准差血清25-羟基维生素D（25[OH]D）11±2.4 ng/mL）和82名对照组参与者（n = 52 [63.4%为女性]，平均±标准差年龄56.40±7.90岁，平均±标准差血清（25[OH]D）53±4.2 ng/mL），这些参与者无心血管疾病。使用超声检查评估颈动脉内膜中层厚度，并通过标准经胸二维超声心动图从胸骨旁长轴视图在舒张末期测量右心室游离壁的心外膜脂肪厚度。
与对照组相比，VDD患者的CIMT和EFT均显著更高（0.75±0.16 mm对0.68±0.21 mm，P < 0.05；0.66±0.15 cm对0.56±0.15 cm，P < 0.001）。
VDD患者似乎有CIMT和EFT增加的情况，这是动脉粥样硬化进程的预测指标。需要进一步研究来证实这些结果。
