显示细胞质透明小球和间质类骨质的恶性纤维组织细胞瘤。一例光镜、电镜、组织化学及免疫组织化学研究的病例报告

Malignant fibrous histiocytoma showing cytoplasmic hyaline globules and stromal osteoids. A case report with light and electron microscopic, histochemical, and immunohistochemical study.

作者信息

Ohmori T, Arita N, Sano A, Uraga N, Tabei R, Sato M, Sakai K, Watanabe Y

出版信息

Acta Pathol Jpn. 1986 Dec;36(12):1931-41. doi: 10.1111/j.1440-1827.1986.tb02258.x.

DOI:10.1111/j.1440-1827.1986.tb02258.x

Abstract

A 56-year-old man died of widespread metastases of malignant fibrous histiocytoma (MFH) primarily developed in the left lower gingiva after a rapid clinical course is reported. Primary and metastatic tumors showed light and electron microscopic, histochemical and immunohistochemical characteristics of MFH together with cytoplasmic hyaline globules and stromal osteoids. Hyaline globules revealed periodic acid-Schiff positive and diastase resistant reactions but not positive with any histochemical and immunohistochemical reactions. Osteoids were partially calcified and rimmed by osteoblastic tumor cells. The present case of MFH may provide difficulties in the differential diagnosis from some osteoid-forming sarcomas in soft tissues with relation to the histogenesis.

摘要

据报道，一名56岁男性因主要发生于左下牙龈的恶性纤维组织细胞瘤（MFH）广泛转移，在经历快速临床病程后死亡。原发性和转移性肿瘤在光镜和电镜下、组织化学和免疫组织化学方面均表现出MFH的特征，同时伴有细胞质透明小球和基质类骨质。透明小球显示过碘酸-希夫反应阳性且对淀粉酶抵抗，但对任何组织化学和免疫组织化学反应均为阴性。类骨质部分钙化，周围有成骨肿瘤细胞环绕。就组织发生而言，本例MFH可能在与某些软组织中形成类骨质的肉瘤进行鉴别诊断时存在困难。