McCombe P A, McManis P G, Frith J A, Pollard J D, McLeod J G
Ann Neurol. 1987 Jan;21(1):102-4. doi: 10.1002/ana.410210120.
In a series of 61 patients with the relapsing variety of chronic inflammatory demyelinating polyneuropathy, there were 16 women of childbearing age, 9 of whom became pregnant. In 4 of these women, the onset of neuropathy occurred in pregnancy and in the other 5 relapses occurred during pregnancy. There was a significant increase in the number of relapses during the year of pregnancy, and a tendency for symptoms to worsen during the third trimester or immediate postpartum period. It is concluded that there is an increased risk of relapse of chronic inflammatory demyelinating polyneuropathy in pregnancy.
在一系列61例复发型慢性炎性脱髓鞘性多发性神经病患者中,有16名育龄妇女,其中9名怀孕。在这些妇女中,4名在怀孕期间出现神经病发作,另外5名在怀孕期间复发。怀孕期间复发次数显著增加,且在妊娠晚期或产后即刻症状有加重趋势。结论是,怀孕期间慢性炎性脱髓鞘性多发性神经病复发风险增加。