Department of Medicine and Nutrition, University of Guanajuato, Campus Leon, Leon, GTO, Mexico.
Unit of Investigative Research on Oncological Diseases, Children's Hospital of Mexico Federico Gomez, Mexico City, Mexico.
J Immunol Res. 2018 Sep 13;2018:2984247. doi: 10.1155/2018/2984247. eCollection 2018.
In recent years, cancer immunotherapy has undergone great advances because of our understanding of the immune response and the mechanisms through which tumor cells evade it. A century after the first immunotherapy attempt based on bacterial products described by William Coley, the use of live attenuated bacterial vectors has become a promising alternative in the fight against cancer. This review describes the role of live attenuated as an oncolytic and immunotherapeutic agent, due to its high affinity for tumor tissue and its ability to activate innate and adaptive antitumor immune response. Furthermore, its potential use as delivery system of tumor antigens and immunomodulatory molecules that induce tumor regression is also reviewed.
近年来，由于我们对免疫反应以及肿瘤细胞逃避免疫反应的机制的理解，癌症免疫疗法取得了重大进展。在基于威廉·科利 (William Coley) 描述的细菌产物的首次免疫疗法尝试一个世纪之后，活减毒细菌载体的使用已成为对抗癌症的一种有前途的选择。由于其对肿瘤组织的高亲和力及其激活先天和适应性抗肿瘤免疫反应的能力，本文综述了活减毒细菌作为溶瘤和免疫治疗剂的作用。此外，还综述了其作为肿瘤抗原和免疫调节分子的递送系统的潜在用途，这些抗原和免疫调节分子可诱导肿瘤消退。
