由活化白细胞介导的铜从铜（I）-硫蛋白转运至脱辅基血浆铜蓝蛋白的过程。
Copper transport from Cu(I)-thionein into apo-caeruloplasmin mediated by activated leucocytes.
作者信息
Schechinger T, Hartmann H J, Weser U
出版信息
Biochem J. 1986 Nov 15;240(1):281-3. doi: 10.1042/bj2400281.
Abstract
A study on the transfer of copper from Cu-thionein into apo-caeruloplasmin, using Cu-thionein that was previously oxidised by activated leucocytes, was performed. Cu(I)-thiolate oxidation was conveniently monitored by the progressive decline of the specific Cotton bands between 400 and 300 nm. The characteristic e.p.r. properties and NN-dimethyl-p-phenylenediamine oxidase activity indicated a successful formation of caeruloplasmin. Taking into account the simultaneous occurrence of leucocytes, apo-caeruloplasmin and Cu-thionein in blood plasma, such an interaction would favour a possible metabolic link between either copper protein.
摘要
利用先前被活化白细胞氧化的铜硫蛋白，开展了一项关于铜从铜硫蛋白向脱辅基血浆铜蓝蛋白转移的研究。通过400至300纳米之间特定科顿带的逐渐下降，可方便地监测硫醇铜（I）的氧化。特征性的电子顺磁共振特性和N，N-二甲基对苯二胺氧化酶活性表明成功形成了血浆铜蓝蛋白。考虑到白细胞、脱辅基血浆铜蓝蛋白和铜硫蛋白同时存在于血浆中，这种相互作用将有利于这两种铜蛋白之间可能存在的代谢联系。
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本文引用的文献
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The purification of human caeruloplasmin.人血浆铜蓝蛋白的纯化
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Development of a radioimmunoassay for rat liver metallothionein-I and its application to the analysis of rat plasma and kidneys.大鼠肝脏金属硫蛋白-I放射免疫测定法的建立及其在大鼠血浆和肾脏分析中的应用。
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Oxidation of Cu(I)-thionein by enzymically generated H2O2.
Hoppe Seylers Z Physiol Chem. 1984 Nov;365(11):1355-9. doi: 10.1515/bchm2.1984.365.2.1355.
7
Yeast copper-thionein can reconstitute the Japanese-lacquer-tree (Rhus vernicifera) laccase from the Type 2-copper-depleted enzyme via a direct copper(I)-transfer mechanism.酵母铜硫蛋白可通过直接的一价铜转移机制，从2型铜缺失的酶中重构日本漆树漆酶。
Biochem J. 1983 May 1;211(2):515-7. doi: 10.1042/bj2110515.
8
Reconstitution of stellacyanin as a case of direct Cu(I) transfer between yeast copper thionein and 'blue' copper apoprotein.作为酵母铜硫蛋白与“蓝色”铜载脂蛋白之间直接铜（I）转移的一个例子，对星蓝蛋白进行重组。
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9
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Identification of an apoceruloplasmin-like substance in the plasma of copper-deficient rats.
J Biol Chem. 1970 May 10;245(9):2350-3.
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