Department of Food Science and Engineering , Jinan University , Guangzhou , Guangdong 510632 , People's Republic of China.
Food and Nutritional Science Program, School of Biological Sciences , The University of Hong Kong , Pok Fu Lam , Hong Kong, People's Republic of China.
J Agric Food Chem. 2018 Oct 31;66(43):11451-11458. doi: 10.1021/acs.jafc.8b04260. Epub 2018 Oct 18.
The absorption of a 5-hydroxymethylfurfural (HMF)-cysteine adduct, 1-dicysteinethioacetal-5-hydroxymethylfurfural (DCH), and its effect on antioxidant activity and gut microbiota were investigated. Results indicated that DCH is more easily absorbed in rats than HMF. Serum DCH concentrations were 15-38-fold of HMF concentrations from 30 to 180 min after intragastrical administration at the level of 100 mg/kg of body weight, and 2.7-4.5% of absorbed DCH was converted to HMF. The malondialdehyde content in the plasma, heart, liver, and kidneys significantly increased after drug (100 mg/kg of bw) administration for 1 week, suggesting that HMF and DCH were oxidative-stress-inducing agents, instead of antioxidant agents, in rats. HMF and DCH also modulated gut microbiota. HMF promoted the growth of Lactobacillus, Tyzzerella, Enterobacter, and Streptococcus. DCH increased the ratio of Firmicutes/ Bacteroidetes and promoted the growth of Akkermansia, Shigella, and Escherichia while inhibiting the growth of Lactobacillus.
研究了 5-羟甲基糠醛（HMF）-半胱氨酸加合物 1-二半胱氨酸硫代乙缩醛-5-羟甲基糠醛（DCH）的吸收及其对抗氧化活性和肠道微生物群的影响。结果表明，DCH 在大鼠体内比 HMF 更容易被吸收。在 100mg/kg 体重水平下，经胃内给予 1 小时后，30 至 180 分钟时血清 DCH 浓度是 HMF 浓度的 15-38 倍，吸收的 DCH 有 2.7-4.5%转化为 HMF。药物（100mg/kg bw）给药 1 周后，血浆、心脏、肝脏和肾脏中的丙二醛含量显著增加，这表明 HMF 和 DCH 是大鼠的氧化应激诱导剂，而不是抗氧化剂。HMF 和 DCH 还调节肠道微生物群。HMF 促进了乳杆菌、泰泽氏菌、肠杆菌和链球菌的生长。DCH 增加了厚壁菌门/拟杆菌门的比例，促进了阿克曼氏菌、志贺氏菌和大肠杆菌的生长，同时抑制了乳杆菌的生长。
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