Aslfalah Hadise, Jamilian Mehri, Khosrowbeygi Ali
a Student Research Committee , Arak University of Medical Sciences , Arak , Iran.
b Endocrinology and Metabolism Research Center, Department of Gynecology and Obstetrics, School of Medicine, Arak University of Medical Sciences , Arak , Iran.
Gynecol Endocrinol. 2019 Mar;35(3):271-275. doi: 10.1080/09513590.2018.1519795. Epub 2018 Oct 10.
Alpha-lipoic acid (ALA) is a short chain fatty acid and is known as a universal antioxidant. The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM). Sixty women diagnosed as GDM during 24 and 28 weeks of pregnancy were randomly divided into drug (n = 30) and placebo (n = 30) groups. They consumed ALA (100 mg) and cellulose acetate (100 mg) respectively for 8 weeks, per day. The biochemical variables were evaluated before and after the trial. Maternal fasting serum values of glucose (p < .001), HOMA-IR (p < .001), MDA/TAC (p < .001), and L/A (p = .008) were decreased while values of adiponectin (p = .011), A/L (p = .001), and A/H (p < .001) were increased in the drug group after the intervention. In summary, current study had shown that after daily supplementation with 100 mg of ALA for 8 weeks in women with GDM, maternal circulating values of adiponectin, A/L, and A/H were increased while values of L/A and MDA/TAC were decreased.
α-硫辛酸（ALA）是一种短链脂肪酸，被誉为通用抗氧化剂。当前这项临床试验研究的目的是探究补充ALA对妊娠期糖尿病（GDM）孕妇血清脂联素（A）、瘦素（L）水平；以及A/L、L/A、脂联素/胰岛素抵抗稳态模型评估（A/H）和丙二醛/总抗氧化能力（MDA/TAC）比值的影响。60名在妊娠24至28周期间被诊断为GDM的女性被随机分为药物组（n = 30）和安慰剂组（n = 30）。她们分别每天服用ALA（100毫克）和醋酸纤维素（100毫克），持续8周。在试验前后评估生化变量。干预后，药物组孕妇空腹血清葡萄糖水平（p <.001）、HOMA-IR（p <.001）、MDA/TAC（p <.001）和L/A（p =.008）降低，而脂联素水平（p =.011）、A/L（p =.001）和A/H（p <.001）升高。总之，当前研究表明，GDM女性每天补充100毫克ALA持续8周后，母体循环中的脂联素、A/L和A/H水平升高，而L/A和MDA/TAC水平降低。
