Gholami Mahsa, Zarei Parvin, Sadeghi Sedeh Bahman, Rafiei Fatemeh, Khosrowbeygi Ali
a Iran Student Research Committee , Arak University of Medical Sciences , Arak , Iran.
b Endocrinology and Metabolism Research Center, Department of Social Medicine, School of Medicine , Arak University of Medical Sciences , Arak , Iran.
Gynecol Endocrinol. 2018 Dec;34(12):1059-1063. doi: 10.1080/09513590.2018.1481944. Epub 2018 Jun 22.
Patients with type 2 diabetes mellitus (T2DM) have been known to be suffering from coenzyme Q10 (CoQ10) deficiency which results in some complications in them. The purpose of this clinical trial study was to evaluate the effects of CoQ10 supplementation on serum values of adiponectin (A), leptin (L), 8-isoprostane, malondialdehyde (MDA), the A/L ratio in women with T2DM. Sixty-eight women with T2DM were enrolled in the current study and were randomly divided into drug (n = 34) and placebo (n = 34) groups who were consuming 100 mg CoQ10 and 100 mg cellulose acetate per day for 12 weeks, respectively. Measurements were performed at the beginning and after the intervention. Serum values of adiponectin (p = .001) and the A/L ratio (p = .001) were increased while values of leptin (p = .041), MDA (p = .023), 8-isoprostane (p = .004) were decreased significantly in drug group after intervention. This study had shown that CoQ10 supplementation in women with T2DM was effective in elevation of adiponectin and the A/L ratio and reduction of leptin, MDA and 8-isoprostane which could result in improving insulin resistance and modulating oxidative stress situation.
已知2型糖尿病（T2DM）患者存在辅酶Q10（CoQ10）缺乏，这会导致他们出现一些并发症。本临床试验研究的目的是评估补充CoQ10对T2DM女性血清脂联素（A）、瘦素（L）、8-异前列腺素、丙二醛（MDA）、A/L比值的影响。68名T2DM女性纳入本研究，随机分为药物组（n = 34）和安慰剂组（n = 34），分别每天服用100 mg CoQ10和100 mg醋酸纤维素，持续12周。在干预开始时和干预后进行测量。干预后，药物组血清脂联素（p = .001）和A/L比值（p = .001）升高，而瘦素（p = .041）、MDA（p = .023）、8-异前列腺素（p = .004）的值显著降低。本研究表明，补充CoQ10对T2DM女性升高脂联素和A/L比值、降低瘦素、MDA和8-异前列腺素有效，这可能有助于改善胰岛素抵抗和调节氧化应激状态。
