College of Physical Education, Changchun Normal University, Changchun, Jilin, China.
Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
PLoS One. 2018 Oct 10;13(10):e0205562. doi: 10.1371/journal.pone.0205562. eCollection 2018.
Aerobic exercise improves cognitive function and adult hippocampal neurogenesis. However, the effects of aerobic exercise combined with strength exercise on cognitive function and adult hippocampal neurogenesis are still unknown. In this study, we established exercise paradigms in rats to mimic aerobic exercise combined with low- and high-intensity strength exercise. We found that aerobic exercise improved spatial learning and memory as well as adult hippocampal neurogenesis, whereas strength exercise suppressed aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in an intensity-dependent manner. Furthermore, the levels of β-hydroxybutyrate (β-HB) and its downstream effector brain-derived neurotrophic factor (BDNF) were increased in the aerobic exercise group, and strength exercise impaired the aerobic exercise-induced increases in β-HB and BDNF mRNA levels. Taken together, these results demonstrated that strength exercise weakened aerobic exercise-induced cognitive improvements and adult hippocampal neurogenesis in rats.
有氧运动可改善认知功能和成年海马神经发生。然而，有氧运动与力量运动相结合对认知功能和成年海马神经发生的影响尚不清楚。在这项研究中，我们建立了大鼠的运动范式，以模拟有氧运动与低强度和高强度力量运动相结合。我们发现，有氧运动改善了空间学习和记忆以及成年海马神经发生，而力量运动则以强度依赖的方式抑制了有氧运动诱导的认知改善和成年海马神经发生。此外，β-羟基丁酸（β-HB）及其下游效应物脑源性神经营养因子（BDNF）的水平在有氧运动组中增加，而力量运动则削弱了有氧运动诱导的β-HB 和 BDNF mRNA 水平的增加。综上所述，这些结果表明，力量运动削弱了大鼠有氧运动诱导的认知改善和成年海马神经发生。
