高脂饮食与体育锻炼的关联对海马体中脑源性神经营养因子表达的影响：一项综述

The Effects of the Association Between a High-Fat Diet and Physical Exercise on BDNF Expression in the Hippocampus: A Comprehensive Review.

作者信息

Gomes Francisca Tayná da Silva, Andrade Antônio Vicente Dias de, Moura Melo Paloma Katlheen, Júnior Roque Ribeiro da Silva, Souza Débora Lopes Silva de, Tavares Élyssa Adriolly Freitas, Sena Ingrid Garcia de, Fernandes Thales Allyrio Araújo de Medeiros, Morais Paulo Leonardo Araújo de Góis, Fonseca Ivana Alice Teixeira, Borges Cibele Dos Santos, Cavalcanti José Rodolfo Lopes de Paiva

机构信息

Faculty of Health Sciences, Department of Biomedical Sciences, Universidade do Estado do Rio Grande do Norte, Mossoró 59633-010, Brazil.

Center for Biological and Health Sciences, Department of Biosciences, Universidade Federal Rural do Semi-Árido, Mossoró 59625-900, Brazil.

出版信息

Life (Basel). 2025 Jun 12;15(6):945. doi: 10.3390/life15060945.

DOI:10.3390/life15060945

PMID:40566596

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12194230/

Abstract

High-fat diets, characterised by their high lipid content, have been associated with structural and functional alterations in the hippocampus of rodents, including a reduction in the expression of brain-derived neurotrophic factor (BDNF), which negatively impacts learning and memory. Evidence suggests that these impairments may be attenuated by regular physical exercise. This review aimed to gather relevant scientific evidence available on the effects of the association between high-fat diets and physical exercise on BDNF expression levels in the hippocampus of rats. The studies analysed highlight a neuroprotective effect of exercise, capable of positively modulating BDNF levels and, consequently, improving the cognitive functions of these animals.

摘要

高脂饮食以其高脂质含量为特征，与啮齿动物海马体的结构和功能改变有关，包括脑源性神经营养因子（BDNF）表达的降低，这对学习和记忆产生负面影响。有证据表明，这些损伤可能会通过定期体育锻炼而减轻。本综述旨在收集关于高脂饮食与体育锻炼之间的关联对大鼠海马体中BDNF表达水平影响的现有相关科学证据。所分析的研究突出了运动的神经保护作用，其能够积极调节BDNF水平，从而改善这些动物的认知功能。