Cezarino Pérsio Yvon Adri, Simões Ricardo Dos Santos, Baracat Edmund Chadat, Soares Junior José Maria
Discipline of Gynecology, Department of Obstetrics and Gynecology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (HC-FMSP), São Paulo, SP, Brazil.
Rev Assoc Med Bras (1992). 2018 May;64(5):469-473. doi: 10.1590/1806-9282.64.05.469.
Some researchers have suggested that HIV infections can increase the cytokines, which might interfere with the bone metabolism and increase the risk of bone mass loss. However, this issue has yet to be consolidated in postmenopausal women.
To analyze studies that evaluated the loss of bone mass through DEXA in women living with HIV. MATERIALS AND METHODS: A systematic review was conducted following the PRISMA guideline. The MEDLINE, EMBASE and Cochrane databases were consulted from January 1987 to March 2017. Studies assessing bone mineral density (BMD) in postmenopausal women living with HIV were included. The secondary outcome was to evaluate the impact of antiretroviral on BMD.
Sixty percent of the manuscripts suggested that women living with HIV had more bone loss than women in the control group, mainly in the lumbar spine. Forty percent did not observe any difference between groups. One study reported the influence of antiretroviral drugs on bone mass but did not find any difference between groups.
Our data suggest that HIV infections may have a negative influence on bone mass loss in women. Further studies on the mechanism of this HIV consequence are necessary to clarify the connection as well as the impact of the antiretroviral action on BMD in postmenopausal women.
一些研究人员认为，HIV感染会增加细胞因子，这可能会干扰骨代谢并增加骨质流失的风险。然而，这一问题在绝经后女性中尚未得到证实。
分析通过双能X线吸收法（DEXA）评估HIV感染女性骨质流失情况的研究。
按照PRISMA指南进行系统评价。检索了1987年1月至2017年3月期间的MEDLINE、EMBASE和Cochrane数据库。纳入评估HIV感染绝经后女性骨矿物质密度（BMD）的研究。次要结果是评估抗逆转录病毒药物对BMD的影响。
60%的研究报告表明，HIV感染女性的骨质流失比对照组女性更多，主要发生在腰椎。40%的研究未观察到两组之间存在任何差异。一项研究报告了抗逆转录病毒药物对骨量的影响，但未发现两组之间存在差异。
我们的数据表明，HIV感染可能对女性骨质流失有负面影响。有必要进一步研究这种HIV相关后果的机制，以阐明其关联以及抗逆转录病毒药物对绝经后女性BMD的影响。
