Stanford University, California.
International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.
J Infect Dis. 2018 Nov 10;218(suppl_4):S222-S226. doi: 10.1093/infdis/jiy543.
With impending rollout of new conjugate typhoid vaccines, better estimates of typhoid case-fatality ratio are needed for countries to set priorities for public health programs. We enrolled 1425 patients of all ages with blood culture-confirmed Salmonella Typhi from laboratory networks serving inpatients and outpatients in Dhaka, Bangladesh. Participants were asked about symptoms and complications including death experienced over a median 3-month period following blood culture diagnosis. Four fatal cases were identified (case-fatality ratio of 0.3% [95% confidence interval, .05%-.55%]). Applying this case-fatality ratio to global typhoid burden estimates would reduce deaths by 70%.
随着新型伤寒结合疫苗即将推出,各国需要更好地估计伤寒病死率,以便为公共卫生项目确定优先事项。我们招募了来自孟加拉国达卡的住院和门诊实验室网络的 1425 名血培养确诊为伤寒沙门氏菌的各年龄段患者。参与者被问及在血培养诊断后中位数为 3 个月的时间内经历的症状和并发症,包括死亡。确定了 4 例死亡病例(病死率为 0.3%[95%置信区间,0.05%-0.55%])。将这一病死率应用于全球伤寒负担估计数,可使死亡人数减少 70%。