National Research & Development Institute for Chemistry and Petrochemistry ICECHIM, 202 Splaiul Independentei, 060021 Bucharest, Romania.
INCDCP-ICECHIM Calarasi Subsidiary, 7A Nicolae Titulescu St., 915300 Lehliu Gara, Romania.
Nutrients. 2018 Oct 9;10(10):1466. doi: 10.3390/nu10101466.
Selenium is essential for humans and the deficit of Se requires supplementation. In addition to traditional forms such as Se salts, amino acids, or selenium-enriched yeast supplements, next-generation selenium supplements, with lower risk for excess supplementation, are emerging. These are based on selenium forms with lower toxicity, higher bioavailability, and controlled release, such as zerovalent selenium nanoparticles (SeNPs) and selenized polysaccharides (SPs). This article aims to focus on the existing analytical systems for the next-generation Se dietary supplement, providing, at the same time, an overview of the analytical methods available for the traditional forms. The next-generation dietary supplements are evaluated in comparison with the conventional/traditional ones, as well as the analysis and speciation methods that are suitable to reveal which Se forms and species are present in a dietary supplement. Knowledge gaps and further research potential in this field are highlighted. The review indicates that the methods of analysis of next-generation selenium supplements should include a step related to chemical species separation. Such a step would allow a proper characterization of the selenium forms/species, including molecular mass/dimension, and substantiates the marketing claims related to the main advantages of these new selenium ingredients.
硒对人体必不可少,人体缺硒则需要进行补充。除了硒盐、氨基酸或富硒酵母等传统形式的补充剂外,还出现了新一代补充剂,其过度补充的风险较低。这些新一代补充剂基于毒性较低、生物利用度较高且具有受控释放的硒形式,例如零价硒纳米颗粒 (SeNPs) 和硒化多糖 (SPs)。本文旨在重点介绍新一代硒膳食补充剂的现有分析系统,同时概述传统形式的可用分析方法。将新一代膳食补充剂与传统/常规补充剂进行了评估,以及适合揭示膳食补充剂中存在哪些硒形态和物种的分析和形态分析方法。突出了该领域的知识空白和进一步研究的潜力。该综述表明,新一代硒补充剂的分析方法应包括与化学形态分离相关的步骤。这样的步骤将允许对硒形态/物种进行适当的表征,包括分子量/尺寸,并证明与这些新型硒成分的主要优势相关的营销主张是合理的。