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通过具有高生物相容性和抗氧化活性的原位生物合成硒纳米颗粒制备的富硒康普茶花粉饮料。

Selenium-Fortified Kombucha-Pollen Beverage by In Situ Biosynthesized Selenium Nanoparticles with High Biocompatibility and Antioxidant Activity.

作者信息

Tritean Naomi, Dima Ștefan-Ovidiu, Trică Bogdan, Stoica Rusăndica, Ghiurea Marius, Moraru Ionuț, Cimpean Anisoara, Oancea Florin, Constantinescu-Aruxandei Diana

机构信息

Bioresources, Polymers and Analysis Departments, National Institute for Research & Development in Chemistry and Petrochemistry-ICECHIM, Splaiul Independenței No. 202, Sector 6, 060021 Bucharest, Romania.

Faculty of Biology, University of Bucharest, Splaiul Independentei No. 91-95, 050095 Bucharest, Romania.

出版信息

Antioxidants (Basel). 2023 Sep 2;12(9):1711. doi: 10.3390/antiox12091711.

DOI:10.3390/antiox12091711
PMID:37760014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10525527/
Abstract

Biogenic selenium nanoparticles (SeNPs) have been shown to exhibit increased bioavailability. Fermentation of pollen by a symbiotic culture of bacteria and yeasts (SCOBY/Kombucha) leads to the release of pollen content and enhances the prebiotic and probiotic effects of Kombucha. The aim of this study was to fortify Kombucha beverage with SeNPs formed in situ by Kombucha fermentation with pollen. Response Surface Methodology (RSM) was used to optimize the biosynthesis of SeNPs and the pollen-fermented Kombucha beverage. SeNPs were characterized by Transmission electron microscopy energy-dispersive X-ray spectroscopy (TEM-EDX), Fourier-transform infrared spectroscopy (FTIR), Dynamic light scattering (DLS), and Zeta potential. The pollen-fermented Kombucha beverage enriched with SeNPs was characterized by measuring the total phenolic content, antioxidant activity, soluble silicon, saccharides, lactic acid, and the total content of Se. The polyphenols were identified by liquid chromatography-mass spectrometry (LC-MS). The pollen and the bacterial (nano)cellulose were characterized by scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX), FTIR, and X-Ray diffraction (XRD). We also assessed the in vitro biocompatibility in terms of gingival fibroblast viability and proliferation, as well as the antioxidant activity of SeNPs and the pollen-fermented Kombucha beverage enriched with SeNPs. The results highlight their increased biological performance in this regard.

摘要

生物源硒纳米颗粒（SeNPs）已被证明具有更高的生物利用度。细菌和酵母共生培养物（SCOBY/康普茶）对花粉进行发酵会导致花粉成分释放，并增强康普茶的益生元和益生菌作用。本研究的目的是用花粉发酵康普茶原位形成的SeNPs强化康普茶饮料。采用响应面法（RSM）优化SeNPs的生物合成以及花粉发酵的康普茶饮料。通过透射电子显微镜能量色散X射线光谱法（TEM-EDX）、傅里叶变换红外光谱法（FTIR）、动态光散射法（DLS）和zeta电位对SeNPs进行表征。通过测量总酚含量、抗氧化活性、可溶性硅、糖类、乳酸和硒的总含量，对富含SeNPs的花粉发酵康普茶饮料进行表征。通过液相色谱-质谱联用（LC-MS）鉴定多酚。通过扫描电子显微镜-能量色散X射线光谱法（SEM-EDX）FTIR和X射线衍射（XRD）对花粉和细菌（纳米）纤维素进行表征。我们还从牙龈成纤维细胞活力和增殖方面评估了体外生物相容性，以及SeNPs和富含SeNPs的花粉发酵康普茶饮料的抗氧化活性。结果突出了它们在这方面增强的生物学性能。

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