槲皮苷元和白杨素：肿瘤细胞系的抗增殖、坏死和凋亡活性。
Quercetagetin and Patuletin: Antiproliferative, Necrotic and Apoptotic Activity in Tumor Cell Lines.
机构信息
Laboratorio 2-10, Departamento de Productos Naturales, Instituto de Química, Universidad Nacional Autónoma de México, 04510 Ciudad de México, Mexico.
Laboratorio 6, 2do piso, UMIEZ, Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, 09230 Ciudad de México, Mexico.
出版信息
Molecules. 2018 Oct 9;23(10):2579. doi: 10.3390/molecules23102579.
Quercetagetin and patuletin were extracted by the same method from two different species that have multiple uses in folk medicine in Mexico and around the globe, one of which is as an anticancer agent. Their biological activity (IC and necrotic, apoptotic and selective activities of these flavonols) was evaluated and compared to that of quercetin, examining specifically the effects of C6 substitution among quercetin, quercetagetin and patuletin. We find that the presence of a methoxyl group in C6 enhances their potency.
栎精和根皮素采用相同方法从两种不同的植物中提取，这两种植物在墨西哥和全球的民间医学中有多种用途，其中一种是作为抗癌剂。评估并比较了它们的生物活性（IC 和坏死、凋亡和这些类黄酮的选择性活性）与槲皮素的生物活性，具体研究了 C6 取代对槲皮素、栎精和根皮素的影响。我们发现 C6 上甲氧基的存在增强了它们的效力。
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