1 Belmont University College of Pharmacy, Nashville, TN, USA.
Ann Pharmacother. 2019 Mar;53(3):316-320. doi: 10.1177/1060028018806624. Epub 2018 Oct 11.
The latest aminophylline shortage has prompted a need for alternative reversal agents for pharmacological stress testing. Cardiac stress testing is common for diagnosis and prognosis in patients with coronary heart disease. Options for pharmacological stress test agents include adenosine, regadenoson, dipyridamole, and dobutamine, whereas aminophylline is the recommended reversal agent. Adenosine and dobutamine can be used as alternatives to regadenoson and dipyridamole to decrease or eliminate the use of aminophylline. Alternatives to aminophylline include theophylline and caffeine. It is important to efficiently identify alternatives during a drug shortage to maintain optimal patient outcomes.
最新的氨茶碱短缺促使人们需要寻找其他药理学应激试验的逆转剂。心脏应激试验常用于冠心病患者的诊断和预后。药理学应激试验药物包括腺苷、雷卡地诺生、双嘧达莫和多巴酚丁胺，而氨茶碱是推荐的逆转剂。腺苷和多巴酚丁胺可以替代雷卡地诺生和双嘧达莫，以减少或消除氨茶碱的使用。氨茶碱的替代品包括茶碱和咖啡因。在药物短缺期间，有效地识别替代品对于维持最佳患者结局非常重要。
