Duan Linshan, Cheng Shuyu, Li Long, Liu Yanling, Wang Dan, Liu Guoyan
School of Pharmaceutical Sciences Xiamen University, Xiamen, China.
Institute of Gastrointestinal Oncology, Medical College of Xiamen University, Xiamen, China.
Front Pharmacol. 2021 Jul 14;12:684486. doi: 10.3389/fphar.2021.684486. eCollection 2021.
Inflammatory bowel disease (IBD) represents chronic recurrent intestinal inflammation resulting from various factors. Crohn's disease (CD) and ulcerative colitis (UC) have been identified as the two major types of IBD. Currently, most of the drugs for IBD used commonly in the clinic have adverse reactions, and only a few drugs present long-lasting treatment effects. Moreover, issues of drug resistance and disease recurrence are frequent and difficult to resolve. Together, these issues cause difficulties in treating patients with IBD. Therefore, the development of novel therapeutic agents for the prevention and treatment of IBD is of significance. In this context, research on natural compounds exhibiting anti-inflammatory activity could be a novel approach to developing effective therapeutic strategies for IBD. Phytochemicals such as astragalus polysaccharide (APS), quercetin, limonin, ginsenoside Rd, luteolin, kaempferol, and icariin are reported to be effective in IBD treatment. In brief, natural compounds with anti-inflammatory activities are considered important candidate drugs for IBD treatment. The present review discusses the potential of certain natural compounds and their synthetic derivatives in the prevention and treatment of IBD.
炎症性肠病（IBD）是由多种因素引起的慢性复发性肠道炎症。克罗恩病（CD）和溃疡性结肠炎（UC）已被确定为IBD的两种主要类型。目前，临床上常用的大多数IBD药物都有不良反应，只有少数药物具有持久的治疗效果。此外，耐药性和疾病复发问题频繁且难以解决。这些问题共同给IBD患者的治疗带来困难。因此，开发用于预防和治疗IBD的新型治疗药物具有重要意义。在这种背景下，对具有抗炎活性的天然化合物进行研究可能是开发IBD有效治疗策略的一种新方法。据报道，黄芪多糖（APS）、槲皮素、柠檬苦素、人参皂苷Rd、木犀草素、山奈酚和淫羊藿苷等植物化学物质在IBD治疗中有效。简而言之，具有抗炎活性的天然化合物被认为是IBD治疗的重要候选药物。本综述讨论了某些天然化合物及其合成衍生物在预防和治疗IBD方面的潜力。
