Yanik G, Radulovacki M
Brain Res. 1987 Feb 3;402(2):362-4. doi: 10.1016/0006-8993(87)90046-1.
Adenosine receptor binding was determined in the brains of rats deprived of rapid eye movement (REM) sleep for 48 and 96 h using [3H]L-phenylisopropyladenosine. Adenosine A1 receptors (Bmax) were significantly increased in the cortex and corpus striatum, and this increase was sleep-specific. Endogenous adenosine was assayed in microwave-fixed brain tissue and no significant changes were found in REM-deprived rats.
使用[3H]L-苯基异丙基腺苷，在剥夺快速眼动（REM）睡眠48小时和96小时的大鼠大脑中测定腺苷受体结合情况。皮质和纹状体中的腺苷A1受体（Bmax）显著增加，且这种增加具有睡眠特异性。在微波固定的脑组织中测定内源性腺苷，发现REM剥夺大鼠中无显著变化。
