a Department of Agrobioscience, Graduate School of Agricultural Science , Kobe University , Kobe , Japan.
b Biotechnology Research Laboratories , Kaneka Corporation Takasago , Hyogo , Japan.
Int J Food Sci Nutr. 2019 May;70(3):294-302. doi: 10.1080/09637486.2018.1508425. Epub 2018 Oct 10.
For over 4000 years, liquorice has been one of the most frequently employed botanicals as a traditional herbal medicine. Although previous reports have found that liquorice flavonoids possess various health beneficial effects, the underlying mechanism responsible for the anti-diabetic effect of liquorice flavonoids remains unclear. The present study demonstrates that liquorice flavonoid oil (LFO) improves type 2 diabetes mellitus through GLUT4 translocation to the plasma membrane by activating both the adenosine monophosphate-activated protein kinase (AMPK) pathway and Akt pathway in muscle of KK-A mice. Furthermore, LFO lowered postprandial hyperglycaemia in a human study. These results indicate that LFO may exert a therapeutic effect on metabolic disorders, such as diabetes and hyperglycaemia, by modulating glucose metabolism through AMPK- and insulin-dependent pathways in skeletal muscle.
甘草作为一种传统草药，已有 4000 多年的应用历史。虽然以往的报告发现甘草类黄酮具有多种有益健康的作用，但甘草类黄酮发挥抗糖尿病作用的潜在机制尚不清楚。本研究表明，甘草类黄酮油（LFO）通过激活 KK-A 小鼠肌肉中的腺苷单磷酸激活蛋白激酶（AMPK）通路和 Akt 通路，促进葡萄糖转运蛋白 4（GLUT4）向质膜转位，从而改善 2 型糖尿病。此外，LFO 还降低了人体餐后高血糖。这些结果表明，LFO 可能通过调节骨骼肌中 AMPK 和胰岛素依赖的途径来改善葡萄糖代谢，从而对代谢紊乱（如糖尿病和高血糖）发挥治疗作用。
