Wei Hui-Jie, Liu Li, Chen Fang-Lian, Wang Dong, Wang Liang, Wang Zeng-Guang, Jiang Rong-Cai, Dong Jing-Fei, Chen Jie-Li, Zhang Jian-Ning
Department of Neurosurgery, Tianjin Medical University General Hospital; Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin, China.
Department of Neurosurgery, Tianjin Medical University General Hospital; Tianjin Neurological Institute; Key Laboratory of Post-trauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education; Tianjin Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin; Department of Neurosurgery, Peking University International Hospital, Beijing, China.
Neural Regen Res. 2019 Jun;14(6):984-990. doi: 10.4103/1673-5374.250577.
Hyperglycemia reduces the number of circulating endothelial progenitor cells, accelerates their senescence and impairs their function. However, the relationship between blood glucose levels and endothelial progenitor cells in peripheral blood of patients with traumatic brain injury is unclear. In this study, 101 traumatic brain injury patients admitted to the Department of Neurosurgery, Tianjin Medical University General Hospital or the Department of Neurosurgery, Tianjin Huanhu Hospital, China, were enrolled from April 2005 to March 2007. The number of circulating endothelial progenitor cells and blood glucose levels were measured at 1, 4, 7, 14 and 21 days after traumatic brain injury by flow cytometry and automatic biochemical analysis, respectively. The number of circulating endothelial progenitor cells and blood sugar levels in 37 healthy control subjects were also examined. Compared with controls, the number of circulating endothelial progenitor cells in traumatic brain injury patients was decreased at 1 day after injury, and then increased at 4 days after injury, and reached a peak at 7 days after injury. Compared with controls, blood glucose levels in traumatic brain injury patients peaked at 1 day and then decreased until 7 days and then remained stable. At 1, 4, and 7 days after injury, the number of circulating endothelial progenitor cells was negatively correlated with blood sugar levels (r = -0.147, P < 0.05). Our results verify that hyperglycemia in patients with traumatic brain injury is associated with decreased numbers of circulating endothelial progenitor cells. This study was approved by the Ethical Committee of Tianjin Medical University General Hospital, China (approval No. 200501) in January 2015.
高血糖会减少循环内皮祖细胞的数量，加速其衰老并损害其功能。然而，创伤性脑损伤患者外周血中血糖水平与内皮祖细胞之间的关系尚不清楚。在本研究中，选取了2005年4月至2007年3月期间入住天津医科大学总医院神经外科或天津市环湖医院神经外科的101例创伤性脑损伤患者。分别在创伤性脑损伤后1、4、7、14和21天，通过流式细胞术和自动生化分析测量循环内皮祖细胞的数量和血糖水平。还检测了37名健康对照者的循环内皮祖细胞数量和血糖水平。与对照组相比，创伤性脑损伤患者的循环内皮祖细胞数量在损伤后1天减少，然后在损伤后4天增加，并在损伤后7天达到峰值。与对照组相比，创伤性脑损伤患者的血糖水平在1天达到峰值，然后下降至7天，之后保持稳定。在损伤后1、4和7天，循环内皮祖细胞数量与血糖水平呈负相关（r = -0.147，P < 0.05）。我们的结果证实，创伤性脑损伤患者的高血糖与循环内皮祖细胞数量减少有关。本研究于2015年1月获得中国天津医科大学总医院伦理委员会批准（批准号：200501）。
