Tominaga T, Imaizumi S, Yoshimoto T, Suzuki J, Fujita Y
Brain Res. 1987 Feb 3;402(2):370-2. doi: 10.1016/0006-8993(87)90048-5.
A spin-trapping technique was applied to the detection of free radicals generated in nicotinamide-adenine denucleotide phosphate (NADPH)-dependent lipid peroxidation of rat ischemic brain homogenate. The spin adduct of phenyl-t-butylnitrone (AN = 16.2-16.5 g, AH beta = 3.6-3.8 g) was observed, and it was thought to be derived from NADPH-dependent lipid peroxidation from its oxygen and NADPH dependency. Its intensity was increased in the recirculated condition following ischemic insult, indicating the susceptibility of brain tissue to lipid peroxidation in such a condition.
一种自旋捕获技术被应用于检测大鼠缺血性脑匀浆中烟酰胺腺嘌呤二核苷酸磷酸（NADPH）依赖性脂质过氧化反应产生的自由基。观察到苯基叔丁基硝酮的自旋加合物（AN = 16.2 - 16.5 g，AHβ = 3.6 - 3.8 g），并且由于其对氧和NADPH的依赖性，认为它源自NADPH依赖性脂质过氧化反应。在缺血性损伤后的再灌注条件下，其强度增加，表明在这种情况下脑组织对脂质过氧化反应的易感性。
