Hellmuth Joanna, Milanini Benedetta, Masliah Eliezer, Tartaglia Maria Carmela, Dunlop Miranda B, Moore David J, Javandel Shireen, DeVaughn Saskia, Valcour Victor
a Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.
b Departments of Neurosciences and Pathology , University of California, San Diego , California, CA, USA.
Neurocase. 2018 Aug;24(4):213-219. doi: 10.1080/13554794.2018.1530362. Epub 2018 Oct 10.
We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes.
我们通过一个病例报告来讨论在感染艾滋病毒的老年人中诊断神经退行性疾病所面临的挑战，该病例报告考虑了阿尔茨海默病（AD）和艾滋病毒相关神经认知障碍（HAND）的神经共同诊断。对该患者进行了4年多的跟踪和评估，并进行了死后神经病理学评估。需要进一步开展工作，以确定能够在感染艾滋病毒且有认知变化的老年人中充分区分HAND与早期神经退行性疾病的诊断测试。
