Rojas Julio C, Stephens Melanie L, Rabinovici Gil D, Kramer Joel H, Miller Bruce L, Seeley William W
a Memory and Aging Center, Department of Neurology , University of California San Francisco , San Francisco, USA.
Neurocase. 2018 Feb;24(1):1-6. doi: 10.1080/13554794.2017.1420199. Epub 2018 Jan 6.
A complex spectrum of mixed brain pathologies is common in older people. This clinical pathologic conference case study illustrates the challenges of formulating clinicopathologic correlations in late-onset neurodegenerative diseases featuring cognitive-behavioral syndromes with underlying multiple proteinopathy. Studies on the co-existence and interactions of Alzheimer's disease (AD) with neurodegenerative non-AD pathologies in the aging brain are needed to understand the pathogenesis of neurodegeneration and to support the development of diagnostic biomarkers and therapies.
在老年人中，复杂的混合性脑病变谱很常见。本临床病理会议病例研究说明了在以认知行为综合征为特征且伴有潜在多种蛋白病变的晚发性神经退行性疾病中建立临床病理相关性所面临的挑战。需要对衰老大脑中阿尔茨海默病（AD）与神经退行性非AD病变的共存及相互作用进行研究，以了解神经退行性变的发病机制，并支持诊断生物标志物和治疗方法的开发。
