垂体切除术、促肾上腺皮质激素片段及丘脑损伤对点燃式癫痫的影响。

The effect of hypophysectomy, ACTH fragments and thalamic lesions upon kindled epilepsy.

作者信息

Rogers O L, Jackson W J

出版信息

Brain Res. 1987 Feb 10;403(1):96-104. doi: 10.1016/0006-8993(87)90127-2.

Abstract

Hypophysectomized rats showed aberrant and retarded rates of kindled epilepsy. In hypophysectomized rats administered adrenocorticotropic hormone (ACTH) subunits ACTH4-10 and ACTH1-24, the normal kindling pattern was restored. However, in hypophysectomized animals which also had lesions of the thalamus (nucleus parafascicularis), ACTH4-10 did not restore the normal pattern of kindling. There have been many conjectures that kindling may be a subcase of learning. These results are compatible with this hypothesis, since the same procedures act in an analogous fashion within avoidance conditioning paradigms.

摘要

垂体切除的大鼠表现出异常且迟缓的点燃癫痫发作率。在给予促肾上腺皮质激素（ACTH）亚基ACTH4 - 10和ACTH1 - 24的垂体切除大鼠中，正常的点燃模式得以恢复。然而，在同时伴有丘脑（束旁核）损伤的垂体切除动物中，ACTH4 - 10并未恢复正常的点燃模式。有许多推测认为点燃可能是学习的一种特殊情况。这些结果与该假设相符，因为相同的程序在回避条件范式中以类似的方式起作用。