Goldman H, Berman R F
Peptides. 1984 Nov-Dec;5(6):1061-5. doi: 10.1016/0196-9781(84)90171-2.
A behaviorally potent analog of ACTH/MSH(4-9), ORG-2766, markedly reduces both physiologic and behavioral components of convulsive seizures in an animal model of epilepsy--the amygdaloid kindled rat. We believe that such non-endocrine analogs of ACTH/MSH fragments may be clinically useful anticonvulsants, particularly in chronic applications, provided that their permeation of the blood-brain barrier can be improved.
促肾上腺皮质激素/促黑素（4-9）的一种具有行为活性的类似物ORG-2766，在癫痫动物模型——杏仁核点燃大鼠中，能显著减轻惊厥性癫痫发作的生理和行为成分。我们认为，促肾上腺皮质激素/促黑素片段的这种非内分泌类似物可能是临床上有用的抗惊厥药，特别是在长期应用时，前提是它们对血脑屏障的通透性能够得到改善。
