Tang Meng-Su, Zhang Shu-Qi, Ma Li-Wei
Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, No. 11 Xinhua Road, Heping District, Shenyang, 110004, Liaoning Province, China.
Department of Ophthalmology, the 463 Hospital of the Chinese People's Liberation Army, Shenyang, 110021, Liaoning Province, China.
BMC Ophthalmol. 2018 Oct 11;18(1):262. doi: 10.1186/s12886-018-0925-9.
To compare the ciliary body changes associated with the use of 23-gauge (23G) and 20-gauge (20G) systems for pars plana vitrectomy.
A total of 60 patients (60 eyes) with idiopathic epiretinal membrane who were scheduled for surgical treatment were selected and randomly assigned to 20G group or 23G group. Time required for incision making, vitrectomy, and incision closure was compared between the two groups. Changes in ciliary body were evaluated by ultrasound microscopy (UBM). Anterior chamber inflammation was assessed with laser flare meter instrument.
Incision-making time (4.5 ± 0.9 min) and incision-closure time (2.8 ± 0.7 min) in the 23G group were significantly shorter than those in the 20G group (10.1 ± 1.5 min and 11.3 ± 2.2 min, respectively). No significant intergroup difference was observed with respect to time required for vitrectomy (21.6 ± 3.3 min and 20.7 ± 3.2 min, respectively). Ciliary body thickness in the 23G group recovered back to preoperative levels after 4 weeks, as against 8 weeks in the 20G group. Postoperative ciliary body thickness in the 20G group was significantly higher than that in the 23G group (p < 0.05). The aqueous protein concentration in 23G group recovered back to preoperative levels after 2 weeks, as against 4 weeks in the 20G group. Postoperative aqueous protein concentration in the 20G group was significantly higher than that in the 23G group (p < 0.05).
The use of 23G system was associated with significantly milder injury to the ciliary body as compared to that associated with the use of 20G system.
The study was retrospectively registered on Chinese Clinical Trial Registry. The clinical study registration number was ChiCTR-INR-17011082 . Date of registration: 2017-04-07.
比较使用23号（23G）和20号（20G）系统进行玻璃体切割术时睫状体的变化。
选取60例计划接受手术治疗的特发性视网膜前膜患者（60只眼），随机分为20G组和23G组。比较两组制作切口、玻璃体切割及关闭切口所需时间。通过超声显微镜（UBM）评估睫状体变化。用激光散射仪评估前房炎症。
23G组制作切口时间（4.5±0.9分钟）和关闭切口时间（2.8±0.7分钟）明显短于20G组（分别为10.1±1.5分钟和11.3±2.2分钟）。两组玻璃体切割所需时间无显著组间差异（分别为21.6±3.3分钟和20.7±3.2分钟）。23G组睫状体厚度在4周后恢复至术前水平，而20G组为8周。20G组术后睫状体厚度明显高于23G组（p<0.05）。23G组房水蛋白浓度在2周后恢复至术前水平，而20G组为4周。20G组术后房水蛋白浓度明显高于23G组（p<0.05）。
与使用20G系统相比，使用23G系统对睫状体的损伤明显更轻。
该研究在中国临床试验注册中心进行回顾性注册。临床研究注册号为ChiCTR-INR-17011082。注册日期：2017年4月7日。
