Hashimoto Daigo
Department of Hematology, Hokkaido University Faculty of Medicine.
Rinsho Ketsueki. 2018;59(10):1886-1894. doi: 10.11406/rinketsu.59.1886.
Emerging evidence has revealed that tissue-resident macrophages (TRMs) are differentiated from fetal precursors, including yolk sac macrophages, and late erythro-myeloid progenitors (EMPs) derived from fetal monocytes. Furthermore, TRMs can locally undergo self-renewal independent of circulating bone marrow-derived monocytes. Recent data has indicated the existence of a TRM niche that controls TRM differentiation, maintenance, and diversification. Niche availability and accessibility for different TRM precursors determine the cell origin of each TRM. Furthermore, the TRM niche in each organ induces epigenetic and gene expression programing to develop the specific functions of each TRM, which are critical for homeostasis maintenance in the corresponding organs. In this review article, we discuss the recent findings concerning TRM differentiation and maintenance from the perspective of TRM niche function.
新出现的证据表明，组织驻留巨噬细胞（TRMs）由胎儿前体细胞分化而来，包括卵黄囊巨噬细胞，以及源自胎儿单核细胞的晚期红系髓系祖细胞（EMPs）。此外，TRMs能够在局部进行自我更新，而不依赖于循环的骨髓来源单核细胞。最近的数据表明存在一个控制TRM分化、维持和多样化的TRM生态位。不同TRM前体细胞对生态位的可利用性和可达性决定了每个TRM的细胞起源。此外，每个器官中的TRM生态位诱导表观遗传和基因表达编程，以发展每个TRM的特定功能，这对于相应器官的稳态维持至关重要。在这篇综述文章中，我们从TRM生态位功能的角度讨论了有关TRM分化和维持的最新发现。
