Takami Akiyoshi
Division of Hematology, Department of Internal Medicine, Aichi Medical University.
Rinsho Ketsueki. 2018;59(10):2349-2353. doi: 10.11406/rinketsu.59.2349.
Platelet transfusion concentrates are commonly used to prevent and treat bleeding due to thrombocytopenia and abnormal platelet function. Although these concentrates are indispensable while safely conducting anticancer chemotherapy and surgery, their use may cause certain adverse effects, including fever, urticaria, anaphylaxis, and transfusion-related acute lung injury. In addition, repeated platelet transfusions may induce allogeneic antibodies, possibly resulting in platelet transfusion refractoriness (PTR). Intrinsically, the use of platelet transfusion concentrates should be carefully administered and reserved to a minimum. This chapter introduces the guidelines based on scientific evidence for the therapeutic use of platelet transfusion concentrates, which The Japan Society of Transfusion Medicine and Cell Therapy recently established.
血小板输注浓缩物常用于预防和治疗血小板减少症及血小板功能异常所致的出血。尽管这些浓缩物在安全进行抗癌化疗和手术时不可或缺，但使用它们可能会引起某些不良反应，包括发热、荨麻疹、过敏反应和输血相关急性肺损伤。此外，反复输注血小板可能会诱导同种异体抗体产生，这可能会导致血小板输注无效（PTR）。本质上，血小板输注浓缩物的使用应谨慎进行，并尽量减少使用。本章介绍了日本输血医学与细胞治疗学会最近制定的基于科学证据的血小板输注浓缩物治疗应用指南。
