Römer Paul, Heimes Diana, Pabst Andreas, Becker Philipp, Thiem Daniel G E, Kämmerer Peer W
Department of Oral- and Maxillofacial Surgery, University Medical Center Mainz, Augustusplatz 2, 55131, Mainz, Germany.
Department of Oral and Maxillofacial Surgery, Federal Armed Forces Hospital, Rübenacher Straße 170, 56072, Koblenz, Germany.
Int J Implant Dent. 2022 Apr 16;8(1):20. doi: 10.1186/s40729-022-00418-2.
Considering a high prevalence of congenital and especially acquired bleeding disorders, their heterogeneity and the multitude of possible treatments strategies, a review of the scientific data on this topic is needed to implement a treatment guide for healthcare professionals.
A selective literature review was performed via PubMed for articles describing oral surgery / dental implant procedures in patients with congenital and acquired bleeding disorders. Out of the existing literature, potential treatment algorithms were extrapolated.
In order to assess the susceptibility to bleeding, risk stratification can be used for both congenital and acquired coagulation disorders. This risk stratification, together with an appropriate therapeutic pathway, allows for an adequate and individualized therapy for each patient. A central point is the close interdisciplinary cooperation with specialists. In addition to the discontinuation or replacement of existing treatment modalities, local hemostyptic measures are of primary importance. If local measures are not sufficient, systemically administered substances such as desmopressin and blood products have to be used.
Despite the limited evidence, a treatment guide could be developed by means of this narrative review to improve safety for patients and practitioners. Prospective randomized controlled trials are needed to allow the implementation of official evidence-based guidelines.
鉴于先天性尤其是获得性出血性疾病的高患病率、其异质性以及众多可能的治疗策略,需要对该主题的科学数据进行综述,以制定针对医疗保健专业人员的治疗指南。
通过PubMed进行选择性文献综述,以查找描述先天性和获得性出血性疾病患者口腔外科手术/牙种植手术的文章。从现有文献中推断出潜在的治疗算法。
为了评估出血易感性,风险分层可用于先天性和获得性凝血障碍。这种风险分层与适当的治疗途径相结合,可为每位患者提供充分且个性化的治疗。关键在于与专家密切的跨学科合作。除了停用或更换现有治疗方式外,局部止血措施至关重要。如果局部措施不足,则必须使用去氨加压素和血液制品等全身给药物质。
尽管证据有限,但通过本叙述性综述可以制定治疗指南,以提高患者和从业者的安全性。需要进行前瞻性随机对照试验,以便实施官方的循证指南。