Ricciardi Luisa, Furci Fabiana, Casciaro Marco, Di Salvo Eleonora, Cristani Mariateresa, Tigano Valeria, Minciullo Paola Lucia, Gangemi Sebastiano
1Allergy and Clinical Immunology Unit, Department of Clinical and Experimental Medicine, University of Messina, AOU Policlinico "G.Martino" Via Consolare Valeria 1, 98124 Messina, Italy.
2Messina Unit, National Research Council of Italy (CNR), Institute of Applied Science and Intelligent System (ISASI), Messina, Italy.
Clin Mol Allergy. 2018 Oct 1;16:21. doi: 10.1186/s12948-018-0099-2. eCollection 2018.
Kounis syndrome (KS) has been described as the coincidental occurrence of acute coronary syndromes during an allergic reaction with cardiac anaphylaxis. It is caused by inflammatory mediators released after exposure to drugs, food, environmental and other triggers. Oxidative stress occurring in various inflammatory disorders causes molecular damage with the production of advanced oxidation products (AOPPs) and advanced glycation end products (AGEs).
Markers of oxidative stress were evaluated in a patient who had experienced KS after antibiotic administration in order to investigate the possible role of these molecules in KS. No data, up to now, are available on biomarkers of oxidative stress in patients with drug-induced KS.
AOPPs, but not AGEs, were significantly increased in the KS affected patient compared to controls as already reported in mastocytosis affected patients.
库尼斯综合征（KS）被描述为在伴有心脏过敏反应的过敏反应期间急性冠状动脉综合征的同时发生。它是由接触药物、食物、环境及其他触发因素后释放的炎症介质引起的。各种炎症性疾病中发生的氧化应激会导致分子损伤，并产生晚期氧化产物（AOPPs）和晚期糖基化终产物（AGEs）。
对一名在使用抗生素后发生KS的患者的氧化应激标志物进行了评估，以研究这些分子在KS中可能发挥的作用。目前尚无关于药物性KS患者氧化应激生物标志物的数据。
与对照组相比，受KS影响的患者体内AOPPs显著增加，而AGEs未增加，这与肥大细胞增多症患者的情况一致。
