皮质 LTP：慢性疼痛的突触模型。

Cortical LTP: A Synaptic Model for Chronic Pain.

机构信息

Department of Physiology, Faculty of Medicine, Centre for the Study of Pain, University of Toronto, Medical Sciences Building, Toronto, Ontario, Canada.

出版信息

Adv Exp Med Biol. 2018;1099:147-155. doi: 10.1007/978-981-13-1756-9_13.

DOI:10.1007/978-981-13-1756-9_13

PMID:30306522

Abstract

Cumulative evidence indicates that cortical synapses not only play important roles in pain perception and related emotional functions but also undergo long-term potentiation (LTP) and contribute to chronic pain. LTP is found at two key cortical regions such as the anterior cingulate cortex (ACC) and insular cortex (IC), and inhibition of cortical LTP produces analgesic effects as well as anxiolytic effects. In this chapter, I will summarize our work on ACC and IC and provide evidence for calcium-stimulated AC1 as a key molecule for cortical LTP and chronic pain.

摘要

累积证据表明，皮质突触不仅在疼痛感知和相关的情绪功能中发挥重要作用，而且还会发生长期增强（LTP），并导致慢性疼痛。LTP 存在于两个关键的皮质区域，如前扣带皮层（ACC）和岛叶皮层（IC），皮质 LTP 的抑制可产生镇痛和抗焦虑作用。在本章中，我将总结我们在 ACC 和 IC 方面的工作，并提供证据表明钙刺激的 AC1 是皮质 LTP 和慢性疼痛的关键分子。