Department of Neuroscience, Jikei University School of Medicine, Tokyo, Japan.
Adv Exp Med Biol. 2018;1099:157-166. doi: 10.1007/978-981-13-1756-9_14.
In addition to the canonical spino-thalamo-cortical pathway, lines of recently accumulated anatomical and physiological evidence suggest that projections originating in nociception-specific neurons in lamina I of the dorsal horn or the spinal nucleus of the trigeminal nerve to the lateral parabrachial nucleus (LPB) and then to the central amygdala (CeA) play essential roles in the nociception-emotion link and its tightening in chronic pain. With recent advances in the artificial manipulation of central neuronal activity, such as those with optogenetics, it is now possible to address many unanswered questions regarding the molecular and cellular mechanisms underlying the plastic changes in this pathway and their role in the pain chronification process.
除了经典的脊髓丘脑皮质通路外，最近积累的解剖和生理学证据表明，起源于背角 I 层或三叉神经脊束核中伤害感受特异性神经元的投射到外侧臂旁核（LPB），然后到杏仁中央核（CeA），在伤害感受-情绪联系及其在慢性疼痛中的加剧中发挥着重要作用。随着在中央神经元活动的人工操作方面的最新进展，如光遗传学，现在可以解决许多关于该通路中可塑性变化的分子和细胞机制及其在疼痛慢性化过程中的作用的未解决问题。
