Kc Elina, Islam Jaisan, Lee Gabsang, Park Young Seok
Program in Neuroscience, Department of Medicine, College of Medicine, Chungbuk National University, Cheongju, Republic of Korea.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mol Neurobiol. 2024 Mar;61(3):1769-1780. doi: 10.1007/s12035-023-03652-w. Epub 2023 Sep 29.
The integration of optogenetics in the trigeminal pain circuitry broadens and reinforces existing pain investigations. Similar to research on spinal neuropathic pain, the exploration of the underlying determinants of orofacial pain is expanding. Optogenetics facilitates more direct, specific, and subtle investigations of the neuronal circuits involved in orofacial pain. One of the most significant concerns of both dentistry and medicine is trigeminal neuralgia (TN) management due to its substantial impact on a patient's quality of life. Our objective is to gather insights from preclinical studies conducted in TN employing an optogenetic paradigm, thereby extending the prospects for in-depth neurobiological research. This review highlights optogenetic research in trigeminal pain circuitry involving TN. We outline the central and peripheral regions associated with pain-that have been investigated using optogenetics in the trigeminal pain circuitry. The study further reports its scope and limitations as well as its potential for future applications from bench to bedside.
光遗传学在三叉神经痛传导通路中的整合拓宽并加强了现有的疼痛研究。与脊髓神经性疼痛的研究类似，对口面部疼痛潜在决定因素的探索也在不断扩展。光遗传学有助于更直接、更具体且更精细地研究参与口面部疼痛的神经回路。由于三叉神经痛（TN）对患者生活质量有重大影响，因此它是牙科和医学最关注的问题之一。我们的目标是从采用光遗传学范式对TN进行的临床前研究中获取见解，从而拓展深入神经生物学研究的前景。本综述重点介绍了涉及TN的三叉神经痛传导通路中的光遗传学研究。我们概述了在三叉神经痛传导通路中使用光遗传学进行研究的与疼痛相关的中枢和外周区域。该研究进一步报告了其范围和局限性以及从实验室到床边的未来应用潜力。
