Lima Fabiano Ferreira de, Da Silva Taís Feitosa, Neto Manoel Miranda, Toscano Luciana Tavares, Da Silva Cássia Surama Oliveira, Silva Alexandre Sérgio
Nutr Hosp. 2018 Oct 8;35(5):1195-1200. doi: 10.20960/nh.1708.
to verify if one single dose of L-arginine improves post-exercise hypotension (PEH) in hypertensive.
double-blind, placebo, randomized with 20 hypertensive (51.47 ± 1.24 years). Two sessions of aerobic exercise were performed proceeded for the ingestion of one dose of 7 g of L-arginine (EX-LARG) or placebo (EX-PLA), plus one session only with L-arginine ingestion (L-ARG). Blood pressure (BP) was measured at rest, and each ten minutes for a period of 60 minutes recovery after exercise. Blood samples were taken before and after exercise for analysis of plasma concentration of nitrite and malondialdehyde (MDA). One-way ANOVA tests were used to compare the baseline conditions and two-way ANOVA, to evaluate possible differences in pressure responses between procedures.
both sessions EX-LARG and EX-PLA showed similar peak reduction for the mean systolic blood pressure (-6.58 ± 0.95 mmHg and -8.38 ± 1.29 mmHg respectively, p = 0.28). On the other hand, for the diastolic component, only L-ARG was able to promote PEH (-1.85 ± 0.44 mmHg), significantly better than EX-PLA (+2.13 ± 0.62 mmHg; p < 0.01). L-ARG alone did not result in significant changes in BP. Nitrite and MDA behaved similarly between procedures.
a single dose of L-arginine before exercise improves diastolic PEH.
验证单剂量L-精氨酸是否能改善高血压患者运动后低血压（PEH）。
采用双盲、安慰剂对照、随机分组，纳入20例高血压患者（51.47±1.24岁）。进行两次有氧运动，分别在运动前摄入7g L-精氨酸（EX-LARG）或安慰剂（EX-PLA），另加一次仅摄入L-精氨酸的试验（L-ARG）。在静息状态下测量血压，并在运动后恢复的60分钟内每隔10分钟测量一次。在运动前后采集血样，分析血浆中亚硝酸盐和丙二醛（MDA）的浓度。采用单因素方差分析比较基线条件，采用双因素方差分析评估不同试验程序之间血压反应的可能差异。
EX-LARG组和EX-PLA组运动后平均收缩压的峰值下降相似（分别为-6.58±0.95mmHg和-8.38±1.29mmHg，p = 0.28）。另一方面，对于舒张压成分，只有L-ARG能够促进运动后低血压（-1.85±0.44mmHg），显著优于EX-PLA组（+2.13±0.62mmHg；p < 0.01）。单独摄入L-ARG并未导致血压出现显著变化。不同试验程序之间亚硝酸盐和MDA的变化情况相似。
运动前单剂量L-精氨酸可改善舒张压运动后低血压。
