Laboratory of Cardiovascular Physiology and Exercise Science, Institute of Biosciences, UNESP, Rio Claro, SP, Brazil; Department of Physical Education, Federal University of Uberlândia, UFU, Uberlândia, MG, Brazil.
Laboratory of Cardiovascular Physiology and Exercise Science, Institute of Biosciences, UNESP, Rio Claro, SP, Brazil.
Life Sci. 2016 Apr 15;151:323-329. doi: 10.1016/j.lfs.2016.02.091. Epub 2016 Mar 10.
After menopause the incidence of cardiovascular diseases increases in women. A decrease in nitric oxide (NO) bioavailability has been pointed out to play a major role in this phenomenon. Since it is believed that l-arginine administration could improve NO bioavailability, the aim of this study was to examine the effects of acute l-arginine administration associated with aerobic exercise on blood pressure (BP), redox state and inflammatory biomarkers in normotensive postmenopausal women (NPW). Sixteen volunteers (57±6yr) were subjected to four experimental sessions (crossover design): arginine+exercise (A-E); arginine (ARG); exercise+placebo (EXE); control (CON). Each session was initiated with either 9g of l-arginine ingestion (ARG or A-E days), placebo (EXE day), or nothing (CON day). The participants performed 30min of aerobic exercise (A-E and EXE days) or sitting rest (CON and ARG days). Blood samples were collected before each session and 45min after the intervention. Office BP and ambulatory blood pressure monitoring (ABPM) were evaluated. NO/cGMP pathway, redox state and inflammatory biomarkers were measured. Systolic BP decreased during the 24-hour in A-E and EXE sessions. However, diastolic BP reduced only in A-E session. No changes were found in the biomarkers concentrations. In conclusion, the association was effective in lowering diastolic BP in NPW. Additionally, physical exercise alone promoted a long lasting effect on systolic BP measured by ABPM in this population, although this beneficial effect was not associated with changes in the cardio-inflammatory biomarkers. Possibly, other factors such as neural influences could be mediating this effect.
绝经后女性心血管疾病的发病率增加。一氧化氮（NO）生物利用度的降低被认为在这一现象中起主要作用。由于人们认为 l-精氨酸的给予可以改善 NO 的生物利用度，因此本研究的目的是检查急性 l-精氨酸给药联合有氧运动对血压（BP）、氧化还原状态和正常血压绝经后妇女（NPW）的炎症生物标志物的影响。16 名志愿者（57±6 岁）接受了四个实验（交叉设计）：精氨酸+运动（A-E）；精氨酸（ARG）；运动+安慰剂（EXE）；对照（CON）。每个疗程开始时，志愿者分别摄入 9g l-精氨酸（ARG 或 A-E 天）、安慰剂（EXE 天）或不摄入任何物质（CON 天）。参与者在 A-E 和 EXE 天进行 30 分钟的有氧运动，或在 CON 和 ARG 天进行静坐休息。在每次疗程前和干预后 45 分钟采集血液样本。评估诊室血压和动态血压监测（ABPM）。测量 NO/cGMP 途径、氧化还原状态和炎症生物标志物。在 A-E 和 EXE 疗程中，24 小时内收缩压降低。然而，只有在 A-E 疗程中舒张压降低。生物标志物浓度没有变化。总之，在 NPW 中，联合使用可有效降低舒张压。此外，单独的运动在该人群中通过 ABPM 对收缩压产生了持久的影响，尽管这种有益的效果与心脏炎症生物标志物的变化无关。可能是其他因素，如神经影响，介导了这种效果。
