Hermus A R, Pieters G F, Pesman G J, Smals A G, Benraad T J, Kloppenborg P W
Eur J Clin Pharmacol. 1987;31(5):609-11. doi: 10.1007/BF00606640.
The response of ACTH to an i.v. bolus injection of 100 micrograms human CRH at 09.00 h was investigated in five healthy men with and without pretreatment with the antiglucocorticoid RU-486 100 mg given orally 7 h before the injection of CRH. In all five subjects the plasma cortisol level immediately before CRH administration at 09.00 h was significantly higher after pretreatment with the antiglucocorticoid (17.1 vs 11.1 micrograms/100 ml). Despite this higher baseline cortisol level, in all subjects the maximal CRH-induced ACTH increase was more pronounced after RU-486 loading (delta max ACTH 39 vs 26 pg/ml). This observation proves that in man physiological concentrations of cortisol determine the response of the pituitary to CRH. Furthermore, the findings suggest reduced circulating glucocorticoid activity after administration of 100 mg RU-486, not completely compensated by an increase in plasma cortisol.
在5名健康男性中，研究了上午9点静脉推注100微克人促肾上腺皮质激素释放激素（CRH）时促肾上腺皮质激素（ACTH）的反应，这些受试者有的在注射CRH前7小时口服100毫克抗糖皮质激素RU - 486进行预处理，有的未进行预处理。在所有5名受试者中，上午9点注射CRH前，经抗糖皮质激素预处理后的血浆皮质醇水平显著高于未预处理者（分别为17.1微克/100毫升和11.1微克/100毫升）。尽管基线皮质醇水平较高，但在所有受试者中，RU - 486负荷后CRH诱导的ACTH最大增加更为明显（最大ACTH变化量分别为39皮克/毫升和26皮克/毫升）。这一观察结果证明，在人体中，生理浓度的皮质醇决定了垂体对CRH的反应。此外，研究结果表明，服用100毫克RU - 486后循环糖皮质激素活性降低，血浆皮质醇增加并不能完全补偿这一降低。
