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[抗孕激素甾体类药物对女性的影响:月经周期和早期妊娠的中断]

[The effects of an antiprogesterone steroid in women: interruption of the menstrual cycle and of early pregnancy].

作者信息

Herrmann W, Wyss R, Riondel A, Philibert D, Teutsch G, Sakiz E, Baulieu E E

出版信息

C R Seances Acad Sci III. 1982 May 17;294(18):933-8.

PMID:6814714
Abstract

RU-486 is a steroid which possesses a great affinity for the progesterone receptor, does not have a progesterone activity, but is indeed a strong antagonist of progesterone effects in animals. Oral administration induces the interruption of the luteal phase of the menstrual cycle and that of early pregnancy in women. Its mode of administration and its properties enable us to envisage a new methodology for menstrual cycle regulation and human birth control.

摘要

RU-486是一种对孕酮受体具有高度亲和力的甾体,它没有孕酮活性,但实际上是动物体内孕酮作用的强拮抗剂。口服可导致女性月经周期黄体期和早期妊娠的中断。其给药方式和特性使我们能够设想一种调节月经周期和人类计划生育的新方法。

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