Centre for Oral Immunobiology & Regenerative Medicine and Centre for Oral Clinical Research, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London (QMUL), London, UK.
Private Practice, London and Bishop's Stortford, UK.
J Clin Periodontol. 2018 Dec;45(12):1458-1464. doi: 10.1111/jcpe.13021. Epub 2018 Nov 5.
The aim of this study was to assess the stability over time of periodontal intrabony defects treated with minimally invasive non-surgical therapy (MINST) and supportive periodontal therapy (SPT).
Clinical and radiographic analysis was carried out in 21 intrabony defects treated with MINST in 14 consecutive patients included in a prospective study and reassessed after 5 years of SPT. Baseline, 1- and 5-year radiographs were analysed, and bone levels were compared by multilevel linear regression adjusted by latent variable method.
None of the 21 teeth with intrabony defects was lost at 5 years. Average probing pocket depth, clinical attachment level and radiographic intrabony vertical defect depth reductions were 3.6, 3.5 and 2.6 mm, respectively, 5 years after treatment (p < 0.001 compared with baseline). Further non-statistically significant reductions were seen in clinical and radiographic measures between 1 and 5 years. Deeper initial defects and narrower angles were predictive of a bigger reduction in defect depth (p < 0.001 and p = 0.017, respectively).
Clinical and radiographic improvements in intrabony defects after MINST seen at 1 year are stable up to 5 years, bringing evidence to support its long-term efficacy for the treatment of intrabony defects in non-smokers.
本研究旨在评估微创非手术治疗（MINST）和辅助牙周治疗（SPT）治疗牙周骨内缺损的长期稳定性。
对 14 例连续患者的 21 个骨内缺损进行 MINST 治疗的前瞻性研究，在 SPT 后 5 年进行临床和影像学分析。对基线、1 年和 5 年的 X 线片进行分析，并通过潜在变量法调整的多层次线性回归比较骨水平。
5 年后，无 21 颗骨内缺损牙脱落。治疗后 5 年，平均探诊袋深度、临床附着丧失和影像学骨内垂直缺损深度分别减少 3.6、3.5 和 2.6mm（与基线相比，p<0.001）。在 1 年至 5 年之间，临床和影像学测量值进一步非显著减少。初始缺损较深和角度较窄预测缺损深度的更大减少（p<0.001 和 p=0.017）。
MINST 治疗后 1 年骨内缺损的临床和影像学改善在 5 年内稳定，为支持其在非吸烟者骨内缺损治疗中的长期疗效提供了证据。
