Vierhapper H, Waldhäusl W
Exp Clin Endocrinol. 1986 Dec;88(3):355-9. doi: 10.1055/s-0029-1210617.
The effect of continuous (50 micrograms and 100 micrograms/4 hrs) versus pulsatile (6.25 micrograms every 30 minutes equivalent to a total dose of 50 micrograms during 4 hours) administration of ovine corticotropin releasing factor (oCRF) was investigated in 6 healthy, male subjects. A rise in the plasma concentrations of ACTH and of cortisol was observed during the intermittent, but not during the continuous infusion of 50 micrograms oCRF/4 hours. Comparing the rise in the plasma concentrations of ACTH and cortisol above individual basal concentrations no differences were found between the continuous infusion of 100 micrograms oCRF and the pulsatile administration of 50 micrograms oCRF. Response to pulsatile (50 micrograms/4 hrs) and continuous (100 micrograms/4 hrs) administration of oCRF, but lack of response to continuous infusion at a rate of 50 micrograms/4 hrs was also reflected by the calculated mean sum of increments of cortisol above individual basal concentrations. These results indicate a superior efficacy of intermittent versus continuous administration of oCRF in healthy man.
在6名健康男性受试者中，研究了连续（50微克和100微克/4小时）与脉冲式（每30分钟6.25微克，相当于4小时内总剂量50微克）给予羊促肾上腺皮质激素释放因子（oCRF）的效果。在间歇性输注50微克oCRF/4小时期间观察到促肾上腺皮质激素（ACTH）和皮质醇的血浆浓度升高，但在连续输注期间未观察到。比较ACTH和皮质醇血浆浓度高于个体基础浓度的升高情况，发现连续输注100微克oCRF与脉冲式给予50微克oCRF之间没有差异。计算出的皮质醇高于个体基础浓度的平均增量总和也反映了对脉冲式（50微克/4小时）和连续（100微克/4小时）给予oCRF的反应，但对以50微克/4小时的速率连续输注无反应。这些结果表明，在健康男性中，间歇性给予oCRF比连续给予具有更高的疗效。
