Noroozinia Farahnaz, Mahmoudzadeh Leila, Gharalari Farzaneh Hosseini, Makhdoomi Khadijeh, Abbasi Ata
Department of Pathology, Urmia University of Medical Sciences School of Medicine, Urmia, Iran.
Nephrology and Renal Transplant Center, Urmia University of Medical Sciences, Urmia, Iran.
Eur J Rheumatol. 2018 Dec;5(4):254-257. doi: 10.5152/eurjrheum.2018.18067. Epub 2018 Oct 10.
Lupus nephritis is one of the most serious and common complications of systemic lupus erythematosus. It has an unpredictable course, and the type, severity, and activity of renal lesions cannot be assessed only by clinical and laboratory findings. The aim of the present study was to determine the relationship between the expression of CD34 and the histopathological findings of lupus nephritis.
A total of 73 renal biopsy samples of patients with a diagnosis of lupus nephritis were examined for CD34 expression by immunohistochemistry. Samples without staining were considered as 0, mild staining as 1+, moderate as 2+, and strong staining as 3+. The relationship between CD34 expression and histopathological and clinical data (including activity index, chronicity index, lupus nephritis class, age, sex, blood pressure, complete blood count, renal function tests, and serological findings) was analyzed.
The mean age of the patients was 29.3±11.3 years. CD34 was expressed in all of the cases but with different intensities. There was a significant relationship between the expression of CD34 and the activity index, as a strong expression was seen in lower activity indices (p<0.001). CD34 expression was correlated with patients' white blood cell (WBC) count and systolic blood pressure (SBP). Patients with strong (score 3) CD34 expression had higher SBPs and lower WBC counts (p=0.03 and 0.04, respectively).
A strong interstitial expression of CD34 was observed in lower activity indices. It seems that CD34 expression could play a protective role in lupus nephritis and could reduce renal activity.
狼疮性肾炎是系统性红斑狼疮最严重且常见的并发症之一。其病程难以预测，肾脏病变的类型、严重程度和活动度不能仅通过临床及实验室检查结果来评估。本研究旨在确定CD34表达与狼疮性肾炎组织病理学表现之间的关系。
对73例诊断为狼疮性肾炎患者的肾活检样本进行免疫组织化学检测，以观察CD34的表达情况。无染色样本记为0，轻度染色记为1+，中度染色记为2+，重度染色记为3+。分析CD34表达与组织病理学及临床数据（包括活动指数、慢性指数、狼疮性肾炎分级、年龄、性别、血压、全血细胞计数、肾功能检查及血清学检查结果）之间的关系。
患者的平均年龄为29.3±11.3岁。所有病例均有CD34表达，但强度不同。CD34表达与活动指数之间存在显著关系，低活动指数时可见强表达（p<0.001）。CD34表达与患者白细胞（WBC）计数及收缩压（SBP）相关。CD34强表达（评分3）的患者收缩压较高，白细胞计数较低（分别为p=0.03和0.04）。
在低活动指数时观察到CD34在间质中有强表达。似乎CD34表达在狼疮性肾炎中可能起保护作用，并可降低肾脏活动度。
