伊朗患者系统性红斑狼疮的遗传与分子生物学：综述
Genetic and molecular biology of systemic lupus erythematosus among Iranian patients: an overview.
作者信息
Gachpazan Meisam, Akhlaghipour Iman, Rahimi Hamid Reza, Saburi Ehsan, Mojarrad Majid, Abbaszadegan Mohammad Reza, Moghbeli Meysam
机构信息
Department of Medical Genetics and Molecular Medicine, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Auto Immun Highlights. 2021 Jan 30;12(1):2. doi: 10.1186/s13317-020-00144-y.
BACKGROUND
Systemic lupus erythematosus (SLE) is a clinicopathologically heterogeneous chronic autoimmune disorder affecting different organs and tissues. It has been reported that there is an increasing rate of SLE incidence among Iranian population. Moreover, the Iranian SLE patients have more severe clinical manifestations compared with other countries. Therefore, it is required to introduce novel methods for the early detection of SLE in this population. Various environmental and genetic factors are involved in SLE progression.
MAIN BODY
In present review we have summarized all of the reported genes which have been associated with clinicopathological features of SLE among Iranian patients.
CONCLUSIONS
Apart from the reported cytokines and chemokines, it was interestingly observed that the apoptosis related genes and non-coding RNAs were the most reported genetic abnormalities associated with SLE progression among Iranians. This review clarifies the genetics and molecular biology of SLE progression among Iranian cases. Moreover, this review paves the way of introducing an efficient panel of genetic markers for the early detection and better management of SLE in this population.
背景
系统性红斑狼疮（SLE）是一种临床病理表现多样的慢性自身免疫性疾病，可累及不同器官和组织。据报道，伊朗人群中SLE的发病率呈上升趋势。此外，与其他国家相比，伊朗SLE患者的临床表现更为严重。因此，需要引入新的方法来早期检测该人群中的SLE。多种环境和遗传因素参与了SLE的病情发展。
主体
在本综述中，我们总结了所有已报道的与伊朗患者SLE临床病理特征相关的基因。
结论
除了已报道的细胞因子和趋化因子外，有趣的是观察到凋亡相关基因和非编码RNA是伊朗人群中与SLE病情发展相关的最常报道的遗传异常。本综述阐明了伊朗患者中SLE病情发展的遗传学和分子生物学。此外，本综述为引入一组有效的遗传标志物以早期检测和更好地管理该人群中的SLE铺平了道路。
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