甲氧苄啶-硫酸多粘菌素B乳膏与夫西地酸乳膏治疗脓疱病的对比

Trimethoprim-polymyxin B sulfate cream versus fusidic acid cream in the treatment of pyodermas.

作者信息

Jaafar R B, Pettit J H, Gibson J R, Harvey S G, Marks P, Webster A

出版信息

Int J Dermatol. 1987 Jan-Feb;26(1):60-3. doi: 10.1111/j.1365-4362.1987.tb04579.x.

DOI:10.1111/j.1365-4362.1987.tb04579.x

Abstract

One hundred patients with a clinical diagnosis of a primary or secondary superficial pyoderma were entered into a double-blind study. They were allocated treatment with either trimethoprim-polymyxin B sulfate cream or fusidic acid cream according to a fully randomized treatment code. Data suitable for evaluation were obtained from 87 patients, and statistical analysis revealed trimethoprim-polymyxin B sulfate (TP) cream to be significantly better than fusidic acid cream in alleviation several of the individual signs and symptoms associated with pyogenic infection of the skin as well as in reducing the overall severity score at the end of the 2-week study period.

摘要

100例临床诊断为原发性或继发性浅表脓皮病的患者进入一项双盲研究。根据完全随机的治疗编码，他们被分配使用甲氧苄啶-硫酸多粘菌素B乳膏或夫西地酸乳膏进行治疗。从87例患者中获得了适合评估的数据，统计分析显示，在为期2周的研究期末，甲氧苄啶-硫酸多粘菌素B（TP）乳膏在减轻与皮肤化脓性感染相关的多个个体体征和症状以及降低总体严重程度评分方面明显优于夫西地酸乳膏。