Radiation Oncology Department, University of Pennsylvania, Philadelphia, PA.
Department of Hematology and Oncology, University of Pennsylvania, Philadelphia, PA.
Semin Radiat Oncol. 2018 Oct;28(4):351-361. doi: 10.1016/j.semradonc.2018.06.004.
Cholangiocarcinoma and gallbladder malignancies are aggressive gastrointestinal malignancies with management dependent on resectability, comorbidities, and location. A multidisciplinary discussion with medical oncologists, radiation oncologists, and surgeons is necessary to determine the optimal treatment approach for each patient. Surgical resection offers the best chance for a long-term cure. Recent studies, such as the phase II SWOG S0809 and the phase III BILCAP study have highlighted the importance of adjuvant treatment with radiation therapy and chemotherapy, respectively, in resected disease. In patients with unresectable disease chemotherapy and chemoradiation therapy to a high dose can improve overall survival and locoregional control. In this expert panel we have brought together radiation oncologists and a medical oncologist to provide case-based feedback on their institutional practices.
胆管癌和胆囊恶性肿瘤是侵袭性的胃肠道恶性肿瘤，其治疗方法取决于可切除性、合并症和肿瘤位置。需要与肿瘤内科医生、放射肿瘤学家和外科医生进行多学科讨论，以确定每位患者的最佳治疗方法。手术切除是长期治愈的最佳机会。最近的研究，如 SWOG S0809 二期研究和 BILCAP 三期研究，分别强调了在可切除疾病中辅助放疗和化疗的重要性。对于不可切除疾病的患者，高剂量化疗和放化疗可以提高总生存期和局部区域控制率。在本专家小组中，我们汇集了放射肿瘤学家和肿瘤内科医生，就其机构实践提供基于病例的反馈。
