Vasiljević Maja, Krstić Vanja, Stanković Sanja, Zrimšek Petra, Svete Alenka Nemec, Seliškar Alenka
Clinic for Small Animal Medicine, Veterinary Faculty, University of Belgrade, Belgrade, Serbia.
Center for Medical Biochemistry, Clinical Center of Serbia, Belgrade, Serbia.
Vet Anaesth Analg. 2018 Nov;45(6):745-753. doi: 10.1016/j.vaa.2018.07.003. Epub 2018 Aug 11.
To investigate changes in serum cardiac troponin I (cTnI) concentrations in dogs in which medetomidine was used for sedation or for premedication prior to anaesthesia with propofol and sevoflurane.
Prospective clinical study.
A total of 66 client-owned dogs.
The dogs were sedated with medetomidine (0.04 mg kg) intravenously (IV) (group M; n = 20) and left to breath room air or anaesthetized with propofol (6.5 ± 0.76 mg kg IV) and sevoflurane (4.5% vaporizer setting) in oxygen (group P + S; n = 20) or with medetomidine (0.04 mg kg IV), propofol (1.92 ± 0.63 mg kg) and sevoflurane (3% vaporizer setting) in oxygen (group M + P + S; n = 26), respectively. After 35 minutes, medetomidine was antagonized with atipamezole (0.1 mg kg intramuscularly). Blood samples for serum cTnI determination were taken before sedation or anaesthesia, 6 and 12 hours and 4 days thereafter. Serum cTnI concentrations were measured with the Architect STAT Troponin-I assay.
Before sedation or anaesthesia, cTnI concentrations were above the detection limit in 22 out of 66 (33%) of dogs. Compared to basal values, cTnI concentrations significantly increased at 6 and 12 hours in all groups and at day 4 in group M. There were no differences in cTnI concentration between groups at baseline, at 6 hours and at 4 days. At 12 hours, cTnI concentrations were significantly higher in groups M and P + S, respectively, compared to group M + P + S.
Oxygenation during anaesthesia and reduction of propofol and sevoflurane dose due to the sparing effects of medetomidine might have played a role in alleviation of myocardial hypoxic injury as indicated by the less severe and short-lived increase of cTnI in the M + P + S group.
研究在使用美托咪定进行镇静或在丙泊酚和七氟醚麻醉前作为术前用药的犬中，血清心肌肌钙蛋白I（cTnI）浓度的变化。
前瞻性临床研究。
总共66只客户拥有的犬。
犬分别通过静脉注射美托咪定（0.04 mg/kg）进行镇静（M组；n = 20），使其呼吸室内空气，或用丙泊酚（6.5±0.76 mg/kg静脉注射）和七氟醚（4.5%蒸发器设定浓度）在氧气中麻醉（P + S组；n = 20），或用美托咪定（0.04 mg/kg静脉注射）、丙泊酚（1.92±0.63 mg/kg）和七氟醚（3%蒸发器设定浓度）在氧气中麻醉（M + P + S组；n = 26）。35分钟后，用阿替美唑（0.1 mg/kg肌肉注射）拮抗美托咪定。在镇静或麻醉前、之后6小时、12小时和4天采集用于测定血清cTnI的血样。用Architect STAT肌钙蛋白-I检测法测量血清cTnI浓度。
在66只犬中的22只（33%）镇静或麻醉前，cTnI浓度高于检测限。与基础值相比，所有组在6小时和12小时时cTnI浓度显著升高，M组在第4天时升高。在基线、6小时和4天时，各组之间cTnI浓度无差异。在12小时时，M组和P + S组的cTnI浓度分别显著高于M + P + S组。
麻醉期间的氧合以及由于美托咪定的节省作用而降低丙泊酚和七氟醚剂量，可能在减轻心肌缺氧损伤中发挥了作用，如M + P + S组中cTnI升高程度较轻且持续时间较短所示。
