Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Wolynska 33, Poznan, Poland.
Sci Rep. 2018 Oct 11;8(1):15164. doi: 10.1038/s41598-018-33327-9.
The global temperatures are increasing. This increase is partly due to methane (CH) production from ruminants, including dairy cattle. Recent studies on dairy cattle have revealed the existence of a heritable variation in CH production that enables mitigation strategies based on selective breeding. We have exploited the available heritable variation to study the genetic architecture of CH production and detected genomic regions affecting CH production. Although the detected regions explained only a small proportion of the heritable variance, we showed that potential QTL regions affecting CH production were located within QTLs related to feed efficiency, milk-related traits, body size and health status. Five candidate genes were found: CYP51A1 on BTA 4, PPP1R16B on BTA 13, and NTHL1, TSC2, and PKD1 on BTA 25. These candidate genes were involved in a number of metabolic processes that are possibly related to CH production. One of the most promising candidate genes (PKD1) was related to the development of the digestive tract. The results indicate that CH production is a highly polygenic trait.
全球气温正在升高。这种升高部分归因于反刍动物（包括奶牛）产生的甲烷（CH）。最近对奶牛的研究揭示了 CH 产量存在可遗传变异，这使得基于选择性繁殖的缓解策略成为可能。我们利用可利用的遗传变异来研究 CH 产量的遗传结构，并检测到影响 CH 产量的基因组区域。尽管检测到的区域仅解释了遗传方差的一小部分，但我们表明，影响 CH 产量的潜在 QTL 区域位于与饲料效率、与牛奶相关的性状、体型和健康状况相关的 QTL 内。发现了五个候选基因：BTA4 上的 CYP51A1、BTA13 上的 PPP1R16B 以及 BTA25 上的 NTHL1、TSC2 和 PKD1。这些候选基因参与了许多可能与 CH 产量相关的代谢过程。最有前途的候选基因之一（PKD1）与消化道的发育有关。结果表明，CH 产量是一个高度多基因性状。
